Young macaques provided the popular antidepressant fluoxetine for two years had lower levels of specific fatty acids and other lipids in their brains than ones not given the drug, discovers a recent research study (July 28) in International Journal of Molecular Sciences. As a more step, the team was interested in getting a more holistic, long-lasting view of what was going on in the monkeys brains– including looking at lipids, because previous work with rodents and reports from human patients had hinted that there may be changes to those biomolecules– but they lacked the capability to do this themselves. “So its not clear if the lipid metabolism would work the same way in humans,” she says.The systems underlying how fluoxetine causes lipid levels to fall and how lower lipid levels might lead to side results likewise need unravelling.Its likely too early to make any significant conclusions, specifically with regard to human beings, says Tkachev.
Young macaques provided the popular antidepressant fluoxetine for two years had lower levels of specific fatty acids and other lipids in their brains than ones not offered the drug, discovers a recent research study (July 28) in International Journal of Molecular Sciences.” While neurotransmitters and genes may get the lions share of the attention in neuroscience research study, brains are mainly made of up fats and other lipids. As a more action, the team was interested in getting a more holistic, long-term view of what was going on in the monkeys brains– including looking at lipids, because previous work with rodents and reports from human clients had actually hinted that there may be modifications to those biomolecules– however they lacked the capacity to do this themselves. “This research study is really interesting due to the fact that it is actually looking at a complete metabolomic profile,” states Levant, something that was not possible until reasonably recently.That stated, there are sticking around concerns, states Levant, such as whether adult animals would display likewise low lipid levels were they on the exact same drug routines as youngsters.Also, as with any non-human animal, macaque bodies arent ensured to work the very same way human bodies do. “So its not clear if the lipid metabolism would work the very same method in people,” she says.The systems underlying how fluoxetine triggers lipid levels to fall and how lower lipid levels might lead to side impacts likewise require unravelling.Its most likely too early to make any major conclusions, especially with regard to people, says Tkachev.