INRS Professor Charles Ramassamy, professional on Alzheimers disease, doctoral student Mohamed Raâfet Ben Khedher and postdoctoral student Mohamed Haddad. Credit: INRS
A well balanced intake of antioxidants could prevent the development of Alzheimers illness.
Research study conducted by the Ph.D trainee Mohamed Raâfet Ben Khedher and the postdoctoral scientist Mohamed Haddad of the Institut national de la recherche scientifique (INRS) has actually revealed that an oxidation-antioxidant imbalance in the blood is an early sign of Alzheimers illness, rather than an effect. This breakthrough made by scientists under the supervision of the Professor Charles Ramassamy offers an opportunity for preventive intervention: the anti-oxidants intake.
The research study group showed that oxidative markers, understood to be associated with Alzheimers illness, show a boost approximately 5 years before the onset of the illness. The results of this research study, released in the Alzheimers & & Dementia: Diagnosis, Assessment & & Disease Monitoring (DADM) journal, recommend that oxidation might be an early marker of this illness that affects more than 500,000 Canadians.
” Given that there is a boost in oxidative stress in people who develop the illness, we may regulate the antioxidant systems. We might modulate the antioxidant systems, such as apolipoproteins J and D, which carry lipids and cholesterol in the blood and play an important role in brain function and Alzheimers illness. The article “Effect of APOE ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in distributing extracellular blisters from cognitively impaired with no dementia participants transformed to Alzheimers illness,” by Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin, and Charles Ramassamy, was published in the Alzheimers & & Dementia: Diagnosis, Assessment & & Disease Monitoring (DADM) journal. The research was supported by a contribution from the Charron household through the Fondation Armand-Frappier, as part of the Louise and André Charron Research Chair on Alzheimers Disease, making it possible for the acquisition of a crucial piece of devices, the NanoSight NS300.
” Given that there is a boost in oxidative stress in individuals who establish the disease, we might manage the antioxidant systems. For instance, we could regulate the antioxidant systems, such as apolipoproteins J and D, which transfer lipids and cholesterol in the blood and play an essential function in brain function and Alzheimers disease. Another avenue would be to increase the intake of anti-oxidants through nutrition,” says Professor Ramassamy..
Available biomarkers.
Unlike the present set of pricey and intrusive tests utilized to detect Alzheimers disease, the oxidative markers found by Professor Ramassamys research group can be identified by a blood test. These markers are discovered in plasma extracellular blisters, which are pockets launched by all cells in the body, consisting of those in the brain..
The research study team focused particularly on the “erratic” Alzheimers illness, the most common kind of the illness which results primarily from the presence of the APOE4 vulnerability gene. This exact same form of the illness had been studied by the group for other early markers.
” By identifying oxidative markers in the blood of individuals at danger 5 years prior to the start of the illness, we might make recommendations to slow the onset of the illness and restrict the risks,” researchers noted.
This development brings brand-new intend to Alzheimers research study. As soon as the disease is symptomatic, it is tough, if not impossible, to reverse it..
About the study.
The post “Effect of APOE ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in circulating extracellular blisters from cognitively impaired with no dementia individuals converted to Alzheimers disease,” by Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin, and Charles Ramassamy, was released in the Alzheimers & & Dementia: Diagnosis, Assessment & & Disease Monitoring (DADM) journal. The research study was supported by a contribution from the Charron family through the Fondation Armand-Frappier, as part of the Louise and André Charron Research Chair on Alzheimers Disease, making it possible for the acquisition of an important piece of equipment, the NanoSight NS300. The research study also received monetary assistance from the Ministère des Relations internationales et de la Francophonie (MRIF), the Institut sur la nutrition et les problems fonctionnels (INAF) and the Quebec Research Network on Aging (RQRV).
Reference: “Effect of APOE ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in circulating extracellular blisters from cognitively impaired with no dementia individuals converted to Alzheimers disease” by Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin and Charles Ramassamy, 14 September 2021, Alzheimers & & Dementia: Diagnosis, Assessment & & Disease Monitoring (DADM). DOI: 10.1002/ dad2.12231.
