Altered function of the red blood cells leads to vascular damage in type 2 diabetes. Results from a brand-new study in cells from patients with type 2 diabetes and mice reveal that this result is triggered by low levels of a crucial molecule in the red blood cells. The researchers found that levels of the little particle microRNA-210 were markedly lowered in red blood cells from 36 patients with type 2 diabetes compared with red blood cells of 32 healthy topics.
Altered function of the red blood cells causes vascular damage in type 2 diabetes. Arise from a brand-new study in cells from clients with type 2 diabetes and mice reveal that this result is brought on by low levels of an essential molecule at a loss blood cells. The study by researchers at Karolinska Institutet in Sweden has been published in the journal Diabetes.
It is popular that patients with type 2 diabetes have an increased danger of cardiovascular illness. In time type 2 diabetes may damage capillary, which might lead to deadly complications such as heart attack and stroke. The disease systems underlying cardiovascular injury in type 2 diabetes are mainly unidentified and there is currently an absence of treatments to prevent such injuries.
In recent years, research has actually shown that the red blood cells, whose most important job is to transport oxygen to physical organs, end up being inefficient in type 2 diabetes and can serve as arbitrators of vascular complications. In the existing study, scientists at Karolinska Institutet have in cells from clients with type 2 diabetes and mice taken a look at which molecular modifications in the red blood cells could describe these hazardous effects in type 2 diabetes.
The researchers discovered that levels of the little molecule microRNA-210 were noticeably decreased in red cell from 36 patients with type 2 diabetes compared to red cell of 32 healthy topics. Micro-RNAs belong to a group of particles that act as regulators of vascular function in diabetes and other conditions. The reduction in microRNA-210 triggered modifications in particular vascular protein levels, and impaired capillary endothelial cell function. In lab experiments, repair of microRNA-210 levels in red cell prevented the development of vascular injury through specific molecular modifications.
” The findings demonstrate a formerly unacknowledged cause of vascular injury in type 2 diabetes,” says Zhichao Zhou, researcher at the Department of Medicine, Solna, Karolinska Institutet, who conducted the research study in cooperation with amongst others Professor John Pernow at the very same department. “We hope that the outcomes will pave the way for brand-new treatments that increase red blood cell microRNA-210 levels and thus avoid vascular injury in patients with type 2 diabetes.”
Referral: “Downregulation of erythrocyte miR-210 induces endothelial dysfunction in type 2 diabetes” by Zhichao Zhou, Aida Collado, Changyan Sun, Yahor Tratsiakovich, Ali Mahdi, Hanna Winter, Ekaterina Chernogubova, Till Seime, Sampath Narayanan, Tong Jiao, Hong Jin, Michael Alvarsson, Xiaowei Zheng, Jiangning Yang, MD, Ulf Hedin, Sergiu-Bogdan Catrina, Lars Maegdefessel and John Pernow, 9 November 2021, Diabetes.DOI: 10.2337/ db21-0093.
The research study was financed by the Swedish Research Council, the Swedish Heart and Lung Foundation, the Diabetes Research Wellness Foundation, the Stockholm County Council ALF, the EFSD/Sanofi European Diabetes Research Programme in Macrovascular Complications, the Loo and Hans Ostermans Foundation, Karolinska Institutet, the Sigurd and Elsa Goljes Memorial Foundation, the Lars Hiertas Memorial Foundation, the von Kantzow Foundation and the Konung Gustaf V: s och Drottning Victorias Frimurarestifelse.