The impact of aspirin on heart failure is controversial. This research study intended to assess its relationship with cardiac arrest occurrence in individuals with and without cardiovascular disease and examine whether utilizing the drug is connected to a brand-new heart failure diagnosis in those at danger.
The analysis included 30,827 individuals at threat for establishing cardiac arrest who were enrolled from Western Europe and the US into the HOMAGE research study. “At risk” was specified as one or more of the following: cigarette smoking, weight problems, high blood pressure, high cholesterol, diabetes, and cardiovascular illness. Participants were aged 40 years and above and without cardiac arrest at baseline. Aspirin use was recorded at enrolment and participants were categorized as non-users or users. Participants were followed up for the very first occurrence of deadly or non-fatal cardiac arrest requiring hospitalization.
The typical age of participants was 67 years and 34% were females. At baseline, an overall of 7,698 participants (25%) were taking aspirin. During the 5.3-year follow-up, 1,330 participants developed heart failure.
The detectives evaluated the association between aspirin use and event heart failure after changing for sex, age, body mass index, smoking, alcohol usage, blood pressure, heart rate, blood cholesterol, creatinine, hypertension, diabetes, heart disease, and treatment with renin-angiotensin-aldosterone-system inhibitors, calcium channel blockers, diuretics, beta-blockers, and lipid-lowering drugs. Taking aspirin was independently associated with a 26% raised risk of a new cardiac arrest diagnosis.
To examine the consistency of the outcomes, the researchers duplicated the analysis after matching aspirin users and non-users for cardiac arrest threat aspects. In this matched analysis, aspirin was associated with a 26% raised danger of a brand-new cardiac arrest medical diagnosis. To inspect the results further, the analysis was repeated after excluding patients with a history of heart disease. In 22,690 individuals (74%) totally free of heart disease, aspirin use was connected with a 27% increased threat of occurrence cardiac arrest.
Dr. Mujaj stated: “This was the first large study to examine the relationship between aspirin usage and event cardiac arrest in individuals with and without heart disease and a minimum of one risk aspect. Aspirin is typically used– in our research study one in 4 participants were taking the medication. In this population, aspirin use was connected with occurrence cardiac arrest, independent of other threat elements.”
He concluded: “Large multinational randomized trials in adults at danger for heart failure are needed to verify these results. Till then, our observations suggest that aspirin ought to be prescribed with care in those with heart failure or with threat factors for the condition.”
Reference: “Aspirin use is associated with increased risk for incident cardiac arrest: a patient-level pooled-analysis” by Mujaj B, Zhang ZY, Yang WY, et al., 22 November 2021, ESC Heart Failure.DOI: 10.1002/ ehf2.13688.
Funding: The European Union (HEALTH-F7-305507 HOMAGE), the European Research Council (Advanced Researcher Grant 2011-294713-EPLORE, the European Research Council Proof-of-Concept Grant 713601-uPROPHET), and the European Research Area Net for Cardiovascular Diseases (JTC2017-046-PROACT) supported the Research Unit Hypertension and Cardiovascular Research. The Non-Profit Association Alliance for the Promotion of Preventive Medicine (APPREMED; URL, http://www.appremed.org), Mechelen, Belgium, received a nonbinding grant from OMRON Healthcare, Co, Ltd, Kyoto, Japan. The sponsors had no role in the preparation of this report.
Aspirin use is associated with a 26% raised risk of heart failure in people with at least one inclining aspect for the condition. To check the consistency of the outcomes, the researchers repeated the analysis after matching aspirin users and non-users for heart failure danger aspects. In 22,690 individuals (74%) free of cardiovascular illness, aspirin usage was associated with a 27% increased danger of incident heart failure.
Dr. Mujaj stated: “This was the first large research study to investigate the relationship between aspirin usage and event heart failure in people with and without heart illness and at least one danger factor. In this population, aspirin use was associated with event heart failure, independent of other danger elements.”
Aspirin usage is associated with a 26% raised danger of heart failure in people with at least one predisposing aspect for the condition. Thats the finding of a research study released today (November 22, 2021) in ESC Heart Failure, a journal of the European Society of Cardiology (ESC). Inclining factors included cigarette smoking, weight problems, hypertension, high cholesterol, diabetes, and heart disease.
” This is the first study to report that amongst individuals with a least one danger aspect for cardiac arrest, those taking aspirin were more likely to subsequently develop the condition than those not utilizing the medication,” said research study author Dr. Blerim Mujaj of the University of Freiburg, Germany. “While the findings need verification, they do suggest that the potential link in between aspirin and cardiac arrest requires to be clarified.”