Researchers examined diffusion tensor imaging (DTI) brain scans from a large dataset of clients between the age of six months and 50 years. DTI is an MRI technique that measures connection in the brain by detecting how water moves along its white matter systems. Water molecules diffuse differently through the brain, depending on the integrity, architecture, and presence of barriers in tissue.
Substantial modifications in the brains white matter in teenagers with autism spectrum condition (ASD). Credit: RSNA and scientist, Clara Weber
” If you consider gray matter as the computer, white matter is like the cables,” Weber stated. “DTI assists us assess how connected and intact those cable televisions are.”
For the study, scientific and DTI information from 583 patients from four current studies of unique patient populations were evaluated: babies– 34 with ASD and 121 controls (34% female, average age 7 months); young children– 57 with ASD and 45 controls (27% woman, mean age 32 months); adolescents– 106 with ASD and 124 controls (49% woman, mean age 158 months); and young adults– 67 with ASD and 29 controls (1% woman, average age 230 months).
” One of the strengths of our research study is that we took a look at a large range of age groups, not simply school-aged kids,” Weber said.
To evaluate the impacts of age and ASD diagnosis on white matter microstructure, the research group created fractional anisotropy, indicate diffusivity and radial diffusivity maps using data from the 4 research studies.
Mean diffusivity is the total mobility of water molecules, which reflects how largely cells are loaded together. Radial diffusivity is the degree water diffuses perpendicular to a white matter system.
” When white matter integrity is interrupted, we see more water diffusing perpendicularly, which equates to a higher radial diffusivity,” Weber stated.
The crucial finding of the analysis was lowered fractional anisotropy within the anterior/middle systems of the corpus callosum in adolescent and young adult ASD clients compared to individuals in the control group. The corpus callosum is a thick package of nerve fibers that links and enables the 2 sides of the brain to interact. Corresponding boosts in ASD-related mean diffusivity and radial diffusivity were found in young people.
” In adolescents, we saw a substantial impact of autism,” Weber said. “In adults, the impact was much more noticable. Our results support the concept of impaired brain connectivity in autism, particularly in systems that connect both hemispheres.”
No decrease in fractional anisotropy was observed in the very same systems in toddlers and infants with ASD compared to controls.
The researchers hope the findings can assist improve early diagnosis of ASD and supply possible unbiased biomarkers to monitor treatment response.
“We need to find more unbiased biomarkers for the disorder that can be used in scientific practice,” Weber said.
Co-authors are Robert T. Constable, Ph.D., Sam Payabvash, M.D., Nigel S. Bamford, M.D., Dustin Scheinost, Ph.D., Stefan P. Haider, and Evelyn M.R. Lake, Ph.D
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Scientists at Yale University examining specialized MRI tests discovered considerable modifications in the microstructure of the brains white matter in adolescents and young people with autism spectrum condition (ASD) compared to a control group, according to research study being presented next week at the yearly meeting of the Radiological Society of North America (RSNA). The changes were most noticable in the area that assists in communication between the 2 hemispheres of the brain.
” One in 68 children in the U.S. is impacted by ASD, however high range in symptom manifestation and severity make it tough to acknowledge the condition early and display treatment reaction,” said Clara Weber, postgraduate research fellow at Yale University School of Medicine. “We aim to discover neuroimaging biomarkers that can possibly assist in medical diagnosis and therapy preparation.”
Scientists evaluated diffusion tensor imaging (DTI) brain scans from a large dataset of clients between the age of six months and 50 years. DTI is an MRI method that measures connectivity in the brain by spotting how water moves along its white matter systems. Water particles diffuse in a different way through the brain, depending on the integrity, architecture, and presence of barriers in tissue.
The crucial finding of the analysis was decreased fractional anisotropy within the anterior/middle tracts of the corpus callosum in young and teen adult ASD patients compared to individuals in the control group. Our results support the concept of impaired brain connection in autism, particularly in tracts that connect both hemispheres.”
