March 29, 2024

New Technology Increases Sequencing Power To Help Decode the Genome of All Life on Earth

The Earlham Institute (EI) has actually enhanced its ability in high-fidelity long-read sequencing with a twin set of the advanced Pacific Biosciences Follow up IIe platforms to support the Earth BioGenome tasks, providing the UK bioscience community with critical technologies for biodiversity genomics.
As the Earth BioGenome Job (EBP) is getting momentum to series, brochure, and define the genomes of all eukaryotic biodiversity in the world within the next 10 years, worldwide efforts are underway to release the innovation and infrastructure capable of quickly delivering big numbers of top quality genome sequences.

The Sequel IIe platform empowers researchers to take genomic analysis to a higher level of accuracy by producing high-fidelity long checks out (HiFi) to deal with genomes and transcriptomes.
” The Sequel IIe platforms permit us to scale up our existing infrastructure in our contribution to BioGenome sequencing,” stated Head of Genomics Pipelines at the Earlham Institute Dr. Karim Gharbi. “Demand from the UK bioscience community for higher-quality genome referrals is growing quickly, with requests to gain access to HiFi sequence data at an all-time high.
Sequel IIe platforms at the Earlham Institute. Credit: Earlham Institute (EI).
” Feedback from early adopters of the Sequel IIe across the genomics community has been very positive with HiFi genomes, outperforming existing resources by at least one order of magnitude. The additional platform will right away double our genome series ability capacity, enabling continued, cost-effective access to HiFi checks out for EI scientists and UK bio-scientists.”.
In the previous few years, the Earlham Institute has made tactical investments in genome-enabling innovations, setting the course for a brand-new age in biology where top quality, richly-annotated genome series are no longer the exception but increasingly the norm.
Director of the Earlham Institute Prof Neil Hall, included: “The Earth BioGenome task efforts are extremely collaborative however the technology and facilities efficient in producing top quality genomes at scale need to be guaranteed. The additional HiFi capability at the Earlham Institute for the analysis of protist genomes strengthens our position in the worldwide effort as a leader in genome sequencing.”.
These sequencing technologies support a number of nationwide and international initiatives with the Earlham Institute as a core research study partner– consisting of the Vertebrate Genomes Project, Darwin Tree of Life (DTOL) Project, and European Reference Genome Atlas (ERGA)– delivering key sequencing data and analyses for a vast array of organisms, and underpinning ambitious program to catalog the biodiversity of single-cell eukaryotes (protists). *.
” Key to this investment was the early adoption of the long, premium (HiFi) sequencing platform (Pacific Biosciences Sequel II) in 2019, prior to the Earlham Institute completely acquired the instrument with support from BBSRC funding,” included Dr. Gharbi. “This innovation allowed the Institutes researchers to protect early success in delivering premium genome recommendations for essential target types and develop EI as a leading center in BioGenome research study.”.
Notes.
* As part of the Wellcome-funded DToL task, the Earlham Institute is likewise leading the advancement of novel tools to build top quality genomes from single-cell eukaryotes. Essential to this technology are platforms and pipelines for protist species isolated from ecological populations to increase efficiency and decrease cost of library preparation from specific cells.