Alzheimers disease is an intricate neurodegenerative disease that engages myriad cellular and molecular players resulting in progressive neuronal loss. Single cell sequencing integrated with spatial methods allow scientists to profile thousands of cells in their native tissue area by charting their physical area. Neighboring cells residing in the very same environment also share various protein and epigenetic markers. Multiomic methods that incorporate single cell gene expression, chromatin state, spatial transcriptomics, and protein expression information paint a complete photo of the brains biological intricacy.
Download this application note from 10x Genomics to find out how a single cell and spatial multiomic technique reveals illness progression and brand-new biomarkers in an Alzheimers mouse model, consisting of
Utilizing single cell gene expression analysis to find cell type– specific markers
Performing motif enrichment analysis of differentially-accessible chromatin areas to recognize plaque-associated transcription factors
Running spatial analysis to discover localized gene expression modifications occurring in discrete anatomical brain areas
