“In a recent study released in Cell, Agudo explained her teams efforts to comprehend the aspects that contribute to breast cancer treatment regression.1 The scientists hunted for immunotherapy-resistant cells and sought to comprehend how they prevented immune cell attack by utilizing the power of Jedi T cells,2 which specifically target and damage cells revealing green fluorescent protein (GFP). By injecting the Jedi cells into mice that reveal GFP, Agudo isolated and imagined cancer cells that endured the T cell attack.Using a mouse model of mammary cancer, Agudo found that the Jedi cells eliminated most GFP cancer cells, but some remained clustered within tumors. They isolated the photoconverted cells, which included cancer cells, immune cells, and helpful fibroblasts, and performed scRNA-seq once again.”References P. Baldominos et al., “Quiescent cancer cells resist T cell attack by forming an immunosuppressive specific niche,” Cell, 185:1694 -1708. J. Agudo et al., “GFP-specific CD8 T cells make it possible for targeted cell deficiency and visualization of T-cell interactions,” Nat Biotechnol, 33:1287 -92, 2015.
“In a recent research study published in Cell, Agudo described her groups efforts to comprehend the aspects that contribute to breast cancer treatment relapse.1 The scientists hunted for immunotherapy-resistant cells and sought to comprehend how they avoided immune cell attack by harnessing the power of Jedi T cells,2 which specifically target and damage cells revealing green fluorescent protein (GFP). By injecting the Jedi cells into mice that express GFP, Agudo isolated and pictured cancer cells that endured the T cell attack.Using a mouse design of mammary carcinoma, Agudo discovered that the Jedi cells killed most GFP cancer cells, however some stayed clustered within growths.”References P. Baldominos et al., “Quiescent cancer cells resist T cell attack by forming an immunosuppressive specific niche,” Cell, 185:1694 -1708.
