How label-free binding platforms work
The pros and cons of common label-free binding assays
Label-free binding assays permit researchers to study how biological molecules engage with each other in conditions that carefully match the particles native biological conformations. A number of methods exist to analyze molecular interactions in near actual time, including bio-layer interferometry, surface area plasmon resonance, isothermal titration calorimetry, and microscale thermophoresis. Since essential experimental parameters, such as throughput, affinity range, and sensitivity, vary between methods, researchers should carefully weigh these aspects when picking the biosensor platform to suit their application and workflow needs.
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