Based upon the previous biosafety research study of 3.5-23.0 Tesla SMF, Xin Zhangs group further increased the electromagnetic field strength and reduced the exposure time. Healthy C57BL/6J mice were exposed to 7.0-33.0 Tesla SMF for one hour.
Experiments performed on SHMFF. Credit: Yue Lyu
After direct exposure, all mice were consistently fed for two months. Other than for a couple of metabolic and liver and hepatorenal function indicators affected by the electromagnetic field, the entire blood count and organ coefficient on histomorphology of primary organs were not seriously afflicted, Most of the mice stayed within the normal recommendation variety.
On the other hand, behavioral tests showed that high SMF eased stress and anxiety and enhanced social and spatial memory in mice within two months after direct exposure.
In addition, behavioral studies of healthy mice exposed to a 3.5-23.0 Tesla electromagnetic field for two hours also discovered enhanced neurocognitive effects, which might be related to increased calcium/calmodulin-dependent protein kinase II expression in the mouse hippocampus.
Zhangs group even more found that 7 Tesla SMF could efficiently eliminate signs of depressed mice. These results not just provide helpful safety information for the advancement of ultra-high MRI, however may likewise suggest that high SMF has the possible to be a future antidepressant treatment.
Referral: “Short- and long-lasting impacts of 3.5– 23.0 Tesla ultra-high magnetic fields on mice behaviour” by Md Hasanuzzaman Khan, Xinfeng Huang, Xiaofei Tian, Changjie Ouyang, Dongmei Wang, Shuang Feng, Jutao Chen, Tian Xue, Jin Bao and Xin Zhang, 16 March 2022, European Radiology.DOI: 10.1007/ s00330-022-08677-8.
This study was supported by the National Key Research & & Development Program of Ministry of Science and Technology, the National Natural Science Foundation of China, the Presidents Fund of Hefei Institutes of Physical Science, etc.
Researchers found strong static magnetic fields can securely eliminate stress and anxiety and depression signs in mice. They think that high static magnetic fields have the potential to be an antidepressant treatment in the future.
Scientists recently carried out a series of research studies to check the biosafety and neurobehavioral impacts of 33.0 Tesla high static electromagnetic fields (SMF) utilizing the self-designed biological research study platform of Steady High Magnetic Field Facility (SHMFF). The experiments were carried out by Prof. Xin Zhangs team at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences.
They, for the very first time, reported the biosafety of 30 Tesla level SMF and the neurobehavioral results of 20 Tesla and 30 Tesla level SMF on healthy mice in the Journal of Magnetic Resonance Imaging and European Radiology.
Recently, ultra-high field magnetic resonance imaging (MRI) has developed rapidly due to its substantial advantage of high imaging resolution. 7 Tesla MRI has been clinically authorized and 21.1 Tesla MRI has been effectively utilized in rodents. Research studies on the biosafety of high magnetic fields above 20 Tesla are still scarce, and there is still a gap in relevant studies above 30 Tesla.
In recent years, ultra-high field magnetic resonance imaging (MRI) has actually developed rapidly due to its significant benefit of high imaging resolution. 7 Tesla MRI has been clinically authorized and 21.1 Tesla MRI has actually been effectively utilized in rodents. Research studies on the biosafety of high magnetic fields above 20 Tesla are still scarce, and there is still a space in relevant studies above 30 Tesla.