March 28, 2024

Surprising Findings – Could Smoking Cessation Drugs Reduce Alcohol Consumption?

The research study found that whether participants were provided nicotine replacement varenicline, treatment, or cytisine, their alcohol consumption dropped after 3 months.
A brand-new research study investigates three cigarette smoking cessation drugs.
Matthew Freiberg, MD, MSc, a research study principal private investigator, Dorothy and Laurence Grossman Chair in Cardiology and teacher of Medicine at VUMC. Credit: Vanderbilt University Medical
A scientific trial to see whether three developed smoking cigarettes cessation treatments might also decrease alcohol usage showed no distinctions in between the medications, although rates of habits change for both alcohol intake and cigarette smoking were high in all treatment groups. According to the findings, these medications may be vital in helping people gave up cigarette smoking and drinking at the exact same time. Suddenly, both the prescription drugs cytisine and varenicline as well as nicotine replacement therapy worked.
400 Russians dealing with HIV got involved in the research study, which was carried out by scientists from the First Pavlov State Medical University of St. Petersburg, Russia, Boston University School of Medicine, Boston Medical Center, and Vanderbilt University Medical Center (VUMC). The research study was just recently published in the journal JAMA Network Open. Volunteers who self-identified as engaged in dangerous drinking and day-to-day smoking were looked for by the researchers, that included HIV researchers and addiction experts. Following their enrolment in the medical trial, participants were followed up with for up to a year. Neither the participants nor the scientists knew which patients were receiving which medication due to the fact that the medications were placebo-controlled.
The research revealed that despite whether subjects got nicotine replacement treatment, varenicline, or cytisine after 3 months, alcohol intake dropped. The main result was the variety of days with heavy drinking in the previous month at 3 months, while the secondary results were alcohol abstinence at three months and cigarette smoking abstaining at six months.

” A single medication to treat both dangerous drinking and smoking cigarettes might enhance health effectively and significantly. Risky drinking and smoking often co-occur, and they both threaten health by increasing threat of cardiovascular illness, cancer, and other important health results,” said the studys lead author, Hilary Tindle, MD, MPH, the William Anderson Spickard, Jr., MD, Professor of Medicine, and associate teacher of Medicine at VUMC..
Scientists are progressively concentrating on comorbidities among individuals living with HIV, such as heart disease and cancer, to enhance their durability due to the fact that there are now effective treatments for the infection.
” It was pleasing to see high-risk research study participants being consisted of in NIH-funded research,” said. Matthew Freiberg, MD, MSc, a study primary investigator, Dorothy and Laurence Grossman Chair in Cardiology, and professor of Medicine at VUMC. “They are not only living with HIV but likewise have a high problem of liver disease, multi-substance use, and psychological health concerns. Such participants are frequently excluded from drug trials. If a medication as simple as nicotine replacement might help them, that would be a win.”.
Freiberg noted that when private investigators had actually designed the research study, they envisioned nicotine replacement as the “control” arm for alcohol consumption. Nicotine replacement treatment has actually been readily available in the United States to treat tobacco dependency because the early 1980s and is not used for the reduction of alcohol consumption.
Hilary Tindle, MD, MPH, the William Anderson Spickard, Jr., MD, Professor of Medicine, and associate teacher of Medicine at VUMC. Credit: Vanderbilt University Medical Center.
The research study enrolled participants who engaged in five or more heavy drinking days in the past month (defined as five or more beverages in one day for a guy or 4 or more beverages in one day for a female) and who smoked 5 or more cigarettes a day.
VUMC scientists dealt with Jeffrey Samet, MD, MA, MPH, John Noble, MD, Professor in General Internal Medicine and professor of Community Health Science at Boston University Schools of Medicine and Public Health, and associates on the research study. Samets research concentrates on substance abuse and HIV infection.
” Another crucial observation in our posthoc analysis was that rates of alcohol usage were lower, and rates of alcohol abstinence were greater, among the people who quit smoking cigarettes as compared to those who continued to smoke. These results require further study to understand if findings was because of the medications directly, giving up smoking cigarettes, or both,” stated Samet, the senior author of the study.
Tindle added that there is much to be learnt more about how the research study drugs– called nicotinic acetylcholine receptor agonists– may work to decrease voluntary alcohol intake. Research studies in animal models show that stimulation of a very specific receptor type consisting of the alpha-four subunit is needed. Importantly, all three of the research study medications target these very receptors.
The investigators concluded that the outcomes of the study, which was performed from July 2017 to December 2020, extend prior work in a number of methods. Especially, this is the largest trial to study nicotinic acetylcholine receptor partial agonists to target alcohol intake and the first to take a look at cytisine to treat both alcohol and tobacco. Cytisine is not yet approved by the U.S. Food and Drug Administration to treat tobacco use but it has been utilized commonly in Eastern Europe for years and is under active research study worldwide.
Referral: “Effectiveness of Varenicline and Cytisine for Alcohol Use Reduction Among People With HIV and Substance UseA Randomized Clinical Trial” by Hilary A. Tindle, MD, Matthew S. Freiberg, MD, Debbie M. Cheng, ScD, Natalia Gnatienko, MPH, Elena Blokhina, MD, Tatiana Yaroslavtseva, MD, Sally Bendiks, MPH, Gregory Patts, MPH, Judith Hahn, Ph.D., Kaku So-Armah, Ph.D., Michael D. Stein, MD, Kendall Bryant, Ph.D., Dmitry Lioznov, MD, Evgeny Krupitsky, MD and Jeffrey H. Samet, MD, 5 August 2022, JAMA Network Open.DOI: 10.1001/ jamanetworkopen.2022.25129.
The study was funded by the National Institute on Alcohol Abuse and Alcoholism.

400 Russians living with HIV took part in the study, which was carried out by scientists from the First Pavlov State Medical University of St. Petersburg, Russia, Boston University School of Medicine, Boston Medical Center, and Vanderbilt University Medical Center (VUMC). Matthew Freiberg, MD, MSc, a research study primary detective, Dorothy and Laurence Grossman Chair in Cardiology, and teacher of Medicine at VUMC. Tindle included that there is much to be learned about how the study drugs– described nicotinic acetylcholine receptor agonists– might work to minimize voluntary alcohol intake. Importantly, all 3 of the study medications target these extremely receptors.
Significantly, this is the biggest trial to study nicotinic acetylcholine receptor partial agonists to target alcohol consumption and the first to examine cytisine to deal with both alcohol and tobacco.