” To date, no alleviative treatment has actually been approved to decrease the progression or treat of knee osteoarthritis,” stated the research studys lead author, Johanna Luitjens, postdoctoral scholar in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. “NSAIDs are often used to deal with pain, however it is still an open discussion of how NSAID use affects outcomes for osteoarthritis patients. In particular, the impact of NSAIDs on synovitis, or the swelling of the membrane lining the joint, has actually never been examined utilizing MRI-based structural biomarkers.”
(A) Normal knee without indications of inflammation. (C) The whole fat pad has a greater signal (light grey color with white lines), which is a sign of progressive inflammation of the knee joint.
Dr. Luitjens and associates set out to examine the association between NSAID use and synovitis in clients with osteoarthritis of the knee and to examine how treatment with NSAIDs affects joint structure with time.
” Synovitis mediates development and progression of osteoarthritis and might be a healing target,” Dr. Luitjens stated. “Therefore, the objective of our study was to evaluate whether NSAID treatment affects the development or progression of synovitis and to investigate whether cartilage imaging biomarkers, which reflect changes in osteoarthritis, are affected by NSAID treatment.”
For the study, 277 individuals from the Osteoarthritis Initiative cohort with moderate to severe osteoarthritis and sustained NSAID treatment for a minimum of one year between baseline and four-year follow-up were included in the research study and compared with a group of 793 control individuals who were not treated with NSAIDs. All participants underwent 3T MRI of the knee initially and after 4 years. Images were scored for biomarkers of inflammation.
Cartilage thickness, structure, and other MRI measurements served as noninvasive biomarkers for assessing arthritis progression.
The outcomes showed no long-lasting benefit of NSAID usage. Joint swelling and cartilage quality were worse at standard in the individuals taking NSAIDs, compared to the control group, and intensified at four-year follow-up.
” In this large group of participants, we were able to reveal that there were no protective systems from NSAIDs in reducing swelling or decreasing the progression of osteoarthritis of the knee joint,” Dr. Luitjens said. “The use of NSAIDs for their anti-inflammatory function has actually been frequently propagated in patients with osteoarthritis recently and need to be revisited, because a favorable effect on joint swelling might not be demonstrated.”
According to Dr. Luitjens, there are several possible reasons NSAID use increases synovitis.
” On the one hand, the anti-inflammatory impact that generally comes from NSAIDs might not effectively prevent synovitis, with progressive degenerative modification leading to aggravating of synovitis in time,” she said. “On the other hand, clients who have synovitis and are taking pain-relieving medications may be physically more active due to pain relief, which could potentially lead to intensifying of synovitis, although we adjusted for physical activity in our design.”
Dr. Luitjens noted that prospective, randomized research studies should be performed in the future to provide conclusive evidence of the anti-inflammatory impact of NSAIDs.
Co-authors are Charles McCulloch, Ph.D., Thomas Link, M.D., Ph.D., Felix Gassert, M.D., Gabby Joseph, Ph.D., and John Lynch, Ph.D
. Meeting: 108th Scientific Assembly and Annual Meeting of the Radiological Society of North America
According to brand-new research study, taking anti-inflammatory painkiller like ibuprofen and naproxen for osteoarthritis may really worsen swelling in the knee joint with time.
Taking anti-inflammatory painkiller like ibuprofen and naproxen for osteoarthritis might get worse inflammation in the knee joint over time. This is according to a new scientific study being provided at the annual conference of the Radiological Society of North America (RSNA) next week.
As the most common kind of arthritis, osteoarthritis (OA) affects more than 32 million grownups in the U.S. and more than 500 million people worldwide. It occurs most regularly in the knees, hips, and hands. In individuals with osteoarthritis, the cartilage that cushions the joint slowly deteriorates. This is why it is sometimes called degenerative joint illness or “tear and wear” arthritis. Arthritis is frequently accompanied by swelling, or swelling, of the joint, which can be uncomfortable.
Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently recommended for osteoarthritis pain and swelling. Common NSAIDs include Ibuprofen (Advil, Motrin) and naproxen (Aleve). However, little is understood about the long-term effects of these drugs on disease progression.
Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently recommended for osteoarthritis discomfort and inflammation. Typical NSAIDs consist of Ibuprofen (Advil, Motrin) and naproxen (Aleve). “NSAIDs are frequently utilized to deal with discomfort, but it is still an open discussion of how NSAID use affects results for osteoarthritis patients. In particular, the effect of NSAIDs on synovitis, or the swelling of the membrane lining the joint, has never been analyzed using MRI-based structural biomarkers.”
For the study, 277 individuals from the Osteoarthritis Initiative friend with moderate to severe osteoarthritis and continual NSAID treatment for at least one year between baseline and four-year follow-up were included in the study and compared with a group of 793 control participants who were not treated with NSAIDs.
