Curcumin, a natural polyphenol, has shown appealing efficacy versus tumors in numerous preclinical designs. Such research studies have reported anecdotal proof of curcumins result in cancer patients.
Curcumins limited bioavailability and low stability have obstructed its medical application to date.
Kanais group has actually found a possible detour around the issue by deductively determining the enzyme GUSB for its crucial function in TBP1901 conversion to curcumin. The scientists hypothesized that this conversion would not be observed in mice with genetically impaired GUSB. They also validated, utilizing a CRISPR-Cas9 screen approach, that curcumin likewise has necessary restorative targets.
” The high conversion rate of TBP1901 to curcumin in bone marrow necessitates its medical application for illness growing in the marrow like multiple myeloma and leukemia,” notes Kanai.
Reference: “Pharmacologic characterization of TBP1901, a prodrug kind of aglycone curcumin, and CRISPR-Cas9 screen for restorative targets of aglycone curcumin” by Tomoyuki Abe, Yoshihito Horisawa, Osamu Kikuchi, Hitomi Ozawa-Umeta, Atsuhiro Kishimoto, Yasuhiro Katsuura, Atsushi Imaizumi, Tadashi Hashimoto, Kotaro Shirakawa, Akifumi Takaori-Kondo, Kosuke Yusa, Tadashi Asakura, Hideaki Kakeya, and Masashi Kanai, 10 October 2022, European Journal of Pharmacology.DOI: 10.1016/ j.ejphar.2022.175321.
The research study was moneyed by the Japan Society for the Promotion of Science..
The high conversion rate of curcumin prodrug TBP1901 to curcumin in bone marrow warrants its scientific application for diseases growing in the marrow like numerous myeloma and leukemia. The natural polyphenol curcumin has shown promising effectiveness with growths in a variety of preclinical designs. Credit: KyotoU/ Global Comms
Prodrug curcumin shows clinical potential..
In cancer medical research studies, curcumin, a natural particle associated to turmeric, has actually been utilized to deal with cancer patients. In spite of its recognized antitumor impacts, drug advancement has actually lagged due to challenges including its chemistry..
Now, a group of researchers at Kyoto University has actually established a prodrug kind of curcumin, TBP1901, that has actually shown anti-tumor impacts without toxicities.
” Curcumin has actually long been utilized as a spice or food coloring, so we anticipate to see minimal adverse effects,” states lead author Masashi Kanai.
The high conversion rate of curcumin prodrug TBP1901 to curcumin in bone marrow warrants its scientific application for diseases growing in the marrow like numerous myeloma and leukemia. The natural polyphenol curcumin has revealed appealing effectiveness with growths in a number of preclinical designs. Kanais group has found a possible detour around the issue by deductively identifying the enzyme GUSB for its essential role in TBP1901 conversion to curcumin.