Tessera is simultaneously establishing and testing 3 classifications of Gene Writing systems– DNA Gene Writers, RNA Gene Writers, and RNA Gene Rewriters.However, for all of its investor interest, Tessera remains something of an enigma to researchers within both academic community and industry who spoke to The Scientist. 3 gene writers under developmentVon Maltzahn tells The Scientist that Tessera is all at once evaluating and developing three classifications of Gene Writing systems– DNA Gene Writers, RNA Gene Writers, and RNA Gene Rewriters– that are delivered to the target site inside a lipid nanoparticle. There are the RNA Gene Writers, which like the RNA Gene Rewriters are obtained from retrotransposons, however which are capable of much longer insertions thanks to differences in the particular RNA design template– encoding enzymes they include.”I believe big gene insertion can be interesting for a variety of diseases,” specifically loss-of-function diseases such as back muscular atrophy, Duchenne muscular dystrophy, or cystic fibrosis, states Alexandra Urman, an expert who covers therapies and the gene editing industry at ARK Investment Management. The company did share a PowerPoint discussion that its scientists provided at the Precision Genome Engineering Keystone Symposia in April, explaining how the business screened for MGEs that might target and overwrite mammalian genes and tested them in human cells.Tessera also shared its presentation from the Federation of American Societies for Experimental Biology (FASEB) Genome Engineering Conference in June, in which the company supplied some preliminary, preclinical information on its Gene Rewriters– a rare disclosure of particular information from a business thats otherwise stayed tight-lipped.
Tessera is concurrently establishing and checking three categories of Gene Writing systems– DNA Gene Writers, RNA Gene Writers, and RNA Gene Rewriters.However, for all of its financier interest, Tessera stays something of an enigma to scientists within both academia and market who spoke to The Scientist. Three gene writers under developmentVon Maltzahn tells The Scientist that Tessera is simultaneously testing and developing 3 classifications of Gene Writing systems– DNA Gene Writers, RNA Gene Writers, and RNA Gene Rewriters– that are delivered to the target site inside a lipid nanoparticle. There are the RNA Gene Writers, which like the RNA Gene Rewriters are obtained from retrotransposons, however which are capable of much longer insertions thanks to distinctions in the particular RNA design template– encoding enzymes they include.