While looking for a brand-new advertisement treatment without major adverse effects, the POSTECH team focused on gossypetin, a flavonoid compound found in hibiscus, likewise called Hibiscus sabdariffa or roselle.
Gossypetin administration and the subsequent modifications in the brain tissue impacted by Alzheimers illness. Credit: POSTECH.
The research study team dealt with AD model mice with gossypetin through intragastric administration for three months and concluded that their impaired memory and cognition were practically brought back to the regular level. They saw a decline in the different types of Aβ aggregates, which are commonly found in the brain tissue with AD-type dementia.
The scientists then collaborated with Professor Jong Kyoung Kim (Department of Life Sciences at POSTECH) and proceeded with single-cell RNA sequencing. The analysis showed that gossypetin avoided the expression of genes associated with gliosis, which promotes persistent inflammatory reactions while increasing the expression of genes associated with Aβ phagocytosis. To put it simply, gossypetin facilitated microglias Aβ clearance.
Teacher Kyong-Tai Kim explained, “We have actually confirmed that getting rid of Aβ aggregates deposited in the brain works in avoiding and treating dementia. Gossypetin from hibiscus will add to the advancement of a budget friendly and safe drug for patients struggling with AD.”.
Reference: “Gossypetin ameliorates 5xFAD spatial learning and memory through boosted phagocytosis versus Aβ” by Kyung Won Jo, Dohyun Lee, Dong Gon Cha, Eunji Oh, Yoon Ha Choi, Somi Kim, Eun Seo Park, Jong Kyoung Kim and Kyong-Tai Kim, 21 October 2022, Alzheimers Research & & Therapy.DOI: 10.1186/ s13195-022-01096-3.
The study was carried out with the support from NovMetaPharma Co., and medical trials are prepared for developing a treatment for dementia prevention and treatment that use gossypetin.
Alzheimers disease is a progressive brain disorder that impacts memory, thinking, and behavior. It is the most common cause of dementia in older adults and is defined by the loss of nerve cells and synapses in the brain. AD begins as Aβ and Tau protein aggregates form deposits in the brain tissue. Microglia internalize such aggregates (phagocytosis) to protect the brain.
Alzheimers illness is a progressive brain disorder that impacts memory, believing, and behavior. It is the most common reason for dementia in older grownups and is identified by the loss of neurons and synapses in the brain. Current research has discovered that a substance in hibiscus has the potential to beat Alzheimers..
There are lots of factors to enjoy a cup of ruby red hibiscus tea, including its capability to warm the body in the winter, enhance the immune system, control blood pressure, and help in weight loss. Now, research study has actually found that it could defeat Alzheimers illness.
Professor Kyong-Tai Kim and Ph.D. prospect Kyung Won Jo, from the Department of Life Sciences at the Pohang University of Science & & Technology (POSTECH), have actually found that the gossypetin in hibiscus triggers microglia, the immune cells in the brain. Their research likewise revealed that these microglia can scavenge amyloid-beta in the brain to enhance cognitive function in people with Alzheimers disease.
AD starts as Aβ and Tau protein aggregates form deposits in the brain tissue. Microglia internalize such aggregates (phagocytosis) to secure the brain. Nevertheless, constant exposure to Aβ will ultimately exhaust the microglia, leading to a persistent inflammatory response and damage in the nerve cells. As an outcome, the victim suffers cognitive decline and memory loss.