Professor Frederic Meunier from the Queensland Brain Institute stated the group had actually recognized brand-new active substances from the mushroom, Hericium erinaceus. This type of edible mushroom, commonly known as the Lions Mane Mushroom, is native to North America, Europe, and Asia. It is commonly looked for after for its distinct flavor and texture, and it is also used in traditional Chinese medicine to increase the immune system and enhance gastrointestinal health.
” Extracts from these so-called lions hair mushrooms have been used in conventional medication in Asian countries for centuries, but we wished to scientifically identify their possible effect on brain cells,” Professor Meunier stated.
” Pre-clinical screening found the lions hair mushroom had a significant effect on the growth of brain cells and improving memory.
” Laboratory tests measured the neurotrophic results of substances isolated from Hericium erinaceus on cultured brain cells, and remarkably we discovered that the active substances promote neuron projections, extending and connecting to other nerve cells.
” Using super-resolution microscopy, we discovered the mushroom extract and its active elements mainly increase the size of development cones, which are especially essential for brain cells to sense their environment and establish brand-new connections with other neurons in the brain.”
Comparison of the control neuron and the giant growth cone of hippocampal nerve cell elicited by the treatment with NDPIH. Credit: UQ
Co-author, UQs Dr. Ramon Martinez-Marmol stated the discovery had applications that might safeguard and treat versus neurodegenerative cognitive disorders such as Alzheimers illness.
” Our idea was to determine bioactive compounds from natural sources that could reach the brain and regulate the development of nerve cells, resulting in improved memory development,” Dr. Martinez-Marmol said.
Dr. Dae Hee Lee from CNGBio Co, which has actually supported and worked together on the research task, stated the properties of lions hair mushrooms had actually been utilized to preserve and treat conditions health in traditional Chinese medication considering that antiquity.
” This crucial research is deciphering the molecular system of lions hair mushroom substances and their results on brain function, particularly memory,” Dr. Lee said.
The study was published in the Journal of Neurochemistry.
Referral: “Hericerin derivatives activates a pan-neurotrophic path in central hippocampal neurons converging to ERK1/2 signaling boosting spatial memory” by Ramón Martínez-Mármol, YeJin Chai, Jacinta N. Conroy, Zahra Khan, Seong-Min Hong, Seon Beom Kim, Rachel S. Gormal, Dae Hee Lee, Jae Kang Lee, Elizabeth J. Coulson, Mi Kyeong Lee, Sun Yeou Kim, Frédéric A. Meunier, 20 January 2023, Journal of Neurochemistry.DOI: 10.1111/ jnc.15767.
UQ acknowledges the collective efforts of scientists from the Republic of Koreas Gachon University and Chungbuk National University.
Researchers discovered lions hair mushroom improved brain cell development and memory in pre-clinical trials. Credit: UQ
Scientists from The University of Queensland have actually found the active compound from an edible mushroom that boosts nerve growth and improves memory.
Teacher Frederic Meunier from the Queensland Brain Institute stated the team had actually identified new active compounds from the mushroom, Hericium erinaceus. This type of edible mushroom, typically referred to as the Lions Mane Mushroom, is native to North America, Europe, and Asia. It is frequently demanded for its unique taste and texture, and it is likewise utilized in standard Chinese medication to boost the immune system and enhance digestive health.
Researchers have actually found lions mane mushrooms improve brain cell development and memory in pre-clinical trials.