” Excessive bleeding is a severe challenge for human health,” Sheikhi said. “With hemorrhaging injuries, it is often the loss of blood– not the injury itself– that triggers death. There is an unmet medical requirement for ready-to-use biomaterials that promote quick blood coagulation.”
Amir Sheikhi, assistant teacher of chemical engineering and biomedical engineering at Penn State, established a model of a microneedle patch that can immediately stop bleeding after an injury. Credit: Kelby Hochreither/Penn State
The hemostatic microneedle innovation developed by Sheikhi can be used like a normal adhesive tape to rapidly stop bleeding. The biodegradable and biocompatible microneedle selections (MNAs) on the patch increase its surface contact with blood and speed up the clotting process. The needles likewise increase the adhesive homes of the patch via mechanical interlocking to promote wound closure.
” In vitro, the crafted MNAs reduced thickening time from 11.5 minutes to 1.3 minutes; and in a rat liver bleeding design, they reduced bleeding by more than 90%,” Sheikhi said. “Those 10 minutes could be the distinction between life and death.”
The MNA spot can be compared to the hydrogel technology that is currently utilized to deal with bleeding injuries in healthcare facilities, however hydrogel applications require preparation and medical knowledge. The microneedle patch is pre-engineered for immediate application that anyone can utilize to stop bleeding, Sheikhi stated, similar to a typical non-prescription adhesive tape.
Microneedles– which are currently in use to deliver biologics, such as drugs or cells, through the skin or for cosmetic treatments to stimulate collagen production– are tiny, making their application pain-free, according to Sheikhi.
The researchers are now working to translate the spot from the lab to the market, with plans to additional test the innovation.
Recommendation: “Tissue adhesive hemostatic microneedle varieties for quick hemorrhage treatment” by Reihaneh Haghniaz, Han-Jun Kim, Hossein Montazerian, Avijit Baidya, Maryam Tavafoghi, Yi Chen, Yangzhi Zhu, Solmaz Karamikamkar, Amir Sheikhi and Ali Khademhosseini, 24 November 2022, Bioactive Materials.DOI: 10.1016/ j.bioactmat.2022.08.017.
All the animal experiments were carried out after the approval of animal protocol by the UCLA Animal Research Committee. Animal handling treatments were carried out following the “Guide for the Care of Laboratory Animals.”.
Sheikhi got financial backing from the Canadian Institutes of Health Research through a postdoctoral fellowship along with the startup fund from The Pennsylvania State University.
Sheikhi started this work as a postdoctoral scholar at the University of California, Los Angeles, in the laboratory of Ali Khademhosseini, now the president of Terasaki Institute for Biomedical Innovation (TIBI). Other UCLA factors include Reihaneh Haghniaz, Hossein Montazerian, Avijit Baidya, Maryam Tavafoghi, and Yi Chen. Han-Jun Kim, Yangzhi Zhu, and Solmaz Karamikamkar, all previously with the Khademhosseini Lab and now all connected with TIBI, also contributed.
Hemostatic microneedle technology can be used like a normal adhesive plaster to stop bleeding quickly. The biocompatible and eco-friendly microneedle arrays (MNAs) on the patch increase its surface area contact with blood to speed up the clotting procedure and likewise increase the adhesive residential or commercial properties of the patch through mechanical interlocking to promote wound closure. The hemostatic microneedle technology developed by Sheikhi can be used like a common adhesive bandage to quickly stop bleeding. The biocompatible and biodegradable microneedle ranges (MNAs) on the spot increase its surface area contact with blood and speed up the clotting process. The needles also increase the adhesive properties of the spot through mechanical interlocking to promote wound closure.
Hemostatic microneedle technology can be applied like a typical adhesive tape to stop bleeding rapidly. The biocompatible and naturally degradable microneedle varieties (MNAs) on the patch increase its surface area contact with blood to speed up the clotting process and likewise increase the adhesive properties of the patch by means of mechanical interlocking to promote wound closure. Credit: Designed by Amir Sheikhi and Reihaneh Haghniaz/Executed by Natan Barros
A soldier sustains a severe gunshot injury in a remote battle zone, or a factory employee experiences a work environment accident and faces a hold-up in reaching the health center due to traffic. Secondary unchecked bleeding resulting from terrible injuries is the leading cause of death for Americans within the age range of one to 46.
Amir Sheikhi, an assistant teacher of chemical engineering and biomedical engineering at Penn State, aims to combat this issue with his ingenious microneedle patch, which has the ability to immediately stop bleeding following an injury.
He set out his prototype in a new paper that will be released in the May concern of Bioactive Materials. The work will be included on the journals cover.