This research study was published on February 22 in the journal Science Advances.
EMS delivery of TBY-robots for long-distance transport throughout several biological barriers. Credit: SIAT
The scientists built the TBY-robot by asymmetrically incapacitating glucose oxidase and catalase onto the surface area of anti-inflammatory nanoparticle-packaged yeast microcapsules. At a homogeneous glucose concentration, the Janus distribution of enzymes can catalyze the decomposition of glucose to generate a local glucose gradient that induces TBY-robot self-propelling motion.
In the presence of an enteral glucose gradient, the oral TBY-robots approach the glucose gradient to permeate the digestive tract mucus barrier and after that cross the intestinal epithelial barrier by microfold cell transcytosis. “We discovered that TBY-robots efficiently penetrated the mucus barrier and notably improved their digestive retention using a dual enzyme-driven engine moving towards the enteral glucose gradient,” said Prof. CAI.
After in situ switching to the macrophage bioengine in Peyers patches, the TBY-robots autonomously move to inflamed websites of the intestinal system through chemokine-guided macrophage relay shipment. “Encouragingly, TBY-robots increased drug build-up at the infected site by approximately 1000-fold, significantly attenuating inflammation and ameliorating disease pathology in mouse models of colitis and gastric ulcers,” said Prof. CAI.
This twin-bioengine delivery technique is a sequence-driven process using EMS, with Peyers spots as transfer stations. This procedure can precisely carry rehabs throughout numerous biological barriers to remote, deep-seated illness sites.
” The transport path resembles that of the Express Mail Service, which specifically delivers parcels to a distant destination using different transportation facilities,” said Prof. CAI. These self-adaptive TBY-robots represent a appealing and safe strategy for the accuracy treatment of intestinal swelling and other inflammatory diseases.
Referral: “Twin-bioengine self-adaptive micro/nanorobots utilizing enzyme actuation and macrophage relay for gastrointestinal inflammation therapy” by Baozhen Zhang, Hong Pan, Ze Chen, Ting Yin, Mingbin Zheng and Lintao Cai, 22 February 2023, Science Advances.DOI: 10.1126/ sciadv.adc8978.
Yeast micro/nanorobots use twin-engine to self-propel in intestinal intraluminal and extraluminal environments. Credit: SIAT
Micro/nanorobots with self-propelling and -browsing abilities have actually attracted substantial attention in drug shipment and therapy owing to their controllable locomotion in hard-to-reach body tissues.
Nevertheless, establishing self-adaptive micro/nanorobots that can change their driving mechanisms across multiple biological barriers to reach remote sores is still a difficulty.
Just recently, a research study team led by Prof. Lintao Cai from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences has established a twin-bioengine yeast micro/nanorobot (TBY-robot) with self-adaptive and self-propelling abilities that can autonomously navigate to irritated sites to provide intestinal inflammation treatment by means of enzyme-macrophage changing (EMS).