” The modifiable way of life intervention utilized by participants in this case series was initially investigated in a pilot scientific trial in which participants (all men in between the ages of 50-72 years) reduced their biological age by approximately 3.23 years as compared to controls. The case series reported on herein was performed to enhance the examination of a modifiable way of life intervention that was largely the exact same in other populations; significantly in ladies.”
The group performed an intervention including an eight-week program. This program consisted of guidance on diet, relaxation, sleep, and workout, extra probiotics and phytonutrients, and dietary training. DNA methylation and biological age analysis (Horvath DNAmAge clock (2013 ), normalized using the SeSAMe pipeline) were performed on blood samples at standard and at the end of the eight-week duration.
Five of the 6 individuals exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biological age. There was a statistically significant (p=.039) distinction in the individuals mean biological age prior to (55.83 years) and after (51.23 years) the 8-week diet plan and way of life intervention, with an average reduction of 4.60 years. The typical chronological age at the start of the program was 57.9 years and all however one individual had a biological age younger than their chronological age at the start of the program, recommending that biological age changes were unrelated to disease improvement and instead may be attributed to underlying aging systems.
” This case series of females individuals extends the previous pilot study of this intervention in males, indicating that beneficial biological age modifications might be possible in both sexes. In addition, the examination of otherwise-healthy individuals, rather than those with detected illness, recommends an influence directly on underlying mechanisms of aging rather of disease-driven aging.”
Recommendation: “Potential reversal of biological age in ladies following an 8-week methylation-supportive diet plan and way of life program: a case series” by Kara N. Fitzgerald, Tish Campbell, Suzanne Makarem and Romilly Hodges, 22 March 2023, Aging.DOI: 10.18632/ aging.204602.
The data recommend “that a methylation-supportive diet plan and way of life intervention might favorably affect biological age in both sexes during middle age and older.”
An 8-week methylation-supportive diet and lifestyle program was found to significantly reduce biological age in a case series of ladies, recommending that such interventions may affect hidden mechanisms of aging instead of disease-driven aging, and be effective for both sexes.
A brand-new term paper released in the journal Aging examines the impact of an unique diet/lifestyle program.
A case series of 6 ladies who underwent a methylation-supportive diet plan and lifestyle program, focused on impacting DNA methylation and procedures of biological aging, was reported on by scientists Kara N. Fitzgerald, Tish Campbell, Suzanne Makarem, and Romilly Hodges. These researchers are related to the Institute for Functional Medicine, Virginia Commonwealth University, and the American Nutrition Association.
Five of the 6 participants displayed a biological age decrease of in between 1.22 and 11.01 years from their standard biological age. There was a statistically considerable (p=.039) distinction in the participants mean biological age prior to (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years. The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age more youthful than their chronological age at the start of the program, recommending that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms.