Researchers from Tohoku Universitys Graduate School of Life Sciences have actually discovered a connection between the neuropeptides that manage food consumption in jellyfish and fruit flies, in spite of their 600 million years of divergence. The team, led by Hiromu Tanimoto and Vladimiros Thoma, found that GLWamide in Cladonema jellyfish and myoinhibitory peptide (MIP) in fruit flies share structural resemblances, recommending an evolutionary link. To explore this phenomenon, a research group has turned to jellyfish and fruit flies, discovering some unexpected results.
” First, to understand systems underlying feeding policy, we compared the gene expression profiles in starving and fed jellyfish,” stated Tanimoto. By synthesizing and checking these neuropeptides, we discovered 5 that decreased feeding in starving jellyfish.”
The jellyfish Cladonema pacificum. Credit: Hiromu Tanimoto
The group, which was led by Hiromu Tanimoto and Vladimiros Thoma from Tohoku Universitys Graduate School of Life Sciences, focused on Cladonema, a little jellyfish with branched tentacles that can be raised in a laboratory. These jellyfish manage just how much they consume based on how starving they are.
” First, to understand systems underlying feeding policy, we compared the gene expression profiles in hungry and fed jellyfish,” said Tanimoto. “The feeding state altered the expression levels of numerous genes, including some that encode neuropeptides. By synthesizing and evaluating these neuropeptides, we found 5 that decreased feeding in hungry jellyfish.”
The scientists then developed in on how one such neuropeptide– GLWamide– controls feeding. When the researchers labelled GLWamide, they discovered it was present in motor neurons located in the arm bases, and feeding increased GLWamide levels.
The GLWamide (green) revealed in neurons surrounding the Cladonema eyelet (black circle). Fruit flies feeding patterns are managed by the neuropeptide myoinhibitory peptide (MIP). Surprisingly, MIP and GLWamide share similarities in their structures, recommending they are related through advancement.
” Since the functions of GLWamide and MIP have been saved regardless of 600 million years of divergence, this led us to contemplate whether it was possible to exchange the two,” said Thoma. “And we did exactly that, first offering MIP to jellyfish and after that revealing GLWamide in flies that had no MIP.”
Astonishingly, MIP reduced Cladonema feeding, simply as GLWamide had. In addition, the GLWamide in flies eliminated their unusual over-eating, indicating the practical conservation of the GLWamide/MIP system in jellyfish and pests.
Tanimoto notes that their research highlights the deep evolutionary origins of a conserved satiety signal and the value of harnessing a relative approach. “We hope that our relative method will inspire focused examination of the role of particles, nerve cells and circuits in managing behavior within a larger evolutionary context.”
Referral: “On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide” by Vladimiros Thoma, Shuhei Sakai, Koki Nagata, Yuu Ishii, Shinichiro Maruyama, Ayako Abe, Shu Kondo, Masakado Kawata, Shun Hamada, Ryusaku Deguchi and Hiromu Tanimoto, 3 April 2023, Proceedings of the National Academy of Sciences.DOI: 10.1073/ pnas.2221493120.
Scientists from Tohoku Universitys Graduate School of Life Sciences have found a connection in between the neuropeptides that control food consumption in jellyfish and fruit flies, regardless of their 600 million years of divergence. The group, led by Hiromu Tanimoto and Vladimiros Thoma, discovered that GLWamide in Cladonema jellyfish and myoinhibitory peptide (MIP) in fruit flies share structural similarities, recommending an evolutionary link. When they exchanged these neuropeptides between the two types, the GLWamide/MIP system still functioned effectively in controlling feeding habits, highlighting the deep evolutionary origins of a saved satiety signal.
Scientists found a connection in between neuropeptides controling food intake in jellyfish and fruit flies, despite 600 million years of divergence. The GLWamide/MIP system controlling feeding behavior was discovered to be functionally saved in between the two species, revealing deep evolutionary origins of a saved satiety signal.
They are discovered in a wide array of organisms like people, mice and fruit flies. To explore this phenomenon, a research study group has actually turned to jellyfish and fruit flies, discovering some surprising results.
Although jellyfish shared a typical ancestor with mammals at least 600 million years back, their bodies are easier; they possess diffused nerve systems called nerve nets, unlike mammals which have more concrete structures such as a brain or ganglia. Still, jellyfish possess a rich repertoire of habits, consisting of fancy foraging methods, mating rituals, sleep and even learning. Despite their important position in the tree of life, these remarkable animals stay understudied, and almost absolutely nothing is understood about how they manage their food consumption.
