Over many years, the scientific neighborhood has actually checked out the capacity of photoacoustic imaging as a tool for biomedical imaging. In this evaluation, the research study group surveys the latest 4 years of research study into conquering the physical and practical difficulties of photoacoustic imaging, with regard to SNR/contrast, spatial resolution, targeted delivery, and clinical application. To encourage more advancements in this framework, the group uses ideas for future research directions that can possibly allow next-generation contrast-enhanced photoacoustic imaging.
Teacher Chulhong Kims team at POSTECH has put together and published a four-year research study in Chemical Reviews on enhancing contrast-enhanced photoacoustic imaging, detailing strategies to conquer its useful and physical difficulties, and recommending future research instructions to possibly allow its next-generation developments. Credit: POSTECH
A group of researchers at POSTECH, directed by Professor Chulhong Kim from the departments of Electrical Engineering, Convergence IT Engineering, and Mechanical Engineering, has recently finished a comprehensive analysis of their revolutionary research in contrast-enhanced photoacoustic imaging. This research study, which spanned the previous 4 years, was recently released in the journal Chemical Reviews.
Over several years, the scientific community has actually explored the capacity of photoacoustic imaging as a tool for biomedical imaging. Despite the improved optical contrast and ultrasonic spatiotemporal resolution it provides, photoacoustic imaging encounters specific physical barriers. These include a low signal-to-noise ratio (SNR), reduced image contrast due to significant optical attenuation, and a lower limitation on spatial resolution when imaging deeply into tissues.
In addition to these challenges, contrast-enhanced photoacoustic imaging encounters useful difficulties such as a lack of reliable cell-specific targeting due to low shipment performance and problems in developing clinically translatable representatives.
Research study image. Credit: POSTECH
It is vital to identify the limitations of traditional photoacoustic imaging in order to assist in the development of this field. This can be achieved through the development of contrast-enhancing representatives, which need to be accompanied by high-performance image acquisition systems to deal with the challenges fundamental to photoacoustic imaging.
In this evaluation, the research team studies the most recent 4 years of research into conquering the physical and practical challenges of photoacoustic imaging, with regard to SNR/contrast, spatial resolution, targeted delivery, and medical application. Additionally, the group supplies a detailed analysis of promising techniques for resolving each challenge, such as photoswitching agents, near-infrared-II agents, super-resolution localization agents, or micromotor representatives. To encourage additional developments in this structure, the group uses ideas for future research study directions that can possibly allow next-generation contrast-enhanced photoacoustic imaging.
Referral: “Recent Advances in Contrast-Enhanced Photoacoustic Imaging: Overcoming the Physical and Practical Challenges” by Wonseok Choi, Byullee Park, Seongwook Choi, Donghyeon Oh, Jongbeom Kim and Chulhong Kim, 16 January 2023, Chemical Reviews.DOI: 10.1021/ acs.chemrev.2 c00627.
The research study was carried out with the support from the National Research Foundation of Korea (NRF) grants moneyed by the Ministry of Science and ICT (MSIT) and the Ministry of Education, Institute of Information and Communications Technology Planning and Evaluation (IITP) grant moneyed by the MSIT, Korea Evaluation Institute of Industrial Technology (KEIT) grant funded by the Ministry of Trade, Industry, and Energy (MOTIE), the Korea Medical Device Development Fund grant funded by the Korea federal government (MSIT, MOTIE, the Ministry of Health and Welfare, the Ministry of Food and Drug Safety) and BK21 FOUR program.
