” You might speculate whether individuals who gain weight again merely lack the appetite-inhibiting effect which neurotensin appears to have,” states senior author Signe Sørensen Torekov. Credit: Cathrine Sixhøj Chrone (University of Copenhagen).
In various countries today, roughly fifty percent of the population is obese, a figure thats on an upward trajectory. While a considerable variety of people have the ability to shed weight, the tough element is keeping that weight reduction.
Current research conducted at the University of Copenhagen recommends that the hormonal agent neurotensin might potentially serve as a predictor for a persons ability to sustain weight reduction.
The study, which has actually been published in the scientific journal Metabolism, is a so-called proof-of-concept research study, which means that it is the very first time that the hormone has actually been examined in relation to weight-loss induced by a low-calorie diet plan.
By University of Copenhagen – The Faculty of Health and Medical Sciences
May 27, 2023
” Initially, we analyzed the impact of weight-loss in obese mice and concluded that weight loss caused reduced amount of the hormonal agent neurotensin. Subsequently, in a medical research study, we found that weight reduction likewise resulted in a decreased amount of neurotensin in human beings. Interestingly, people who maintained weight-loss released more neurotensin than people who restored weight once again,” explains Professor Signe Sørensen Torekov, who is the last author of the research study, at the Department of Biomedical Sciences at the University of Copenhagen.
” It might help describe why some people are more effective than others at maintaining weight reduction.”.
Like other hunger gut hormones, neurotensin is released by the intestinal tracts when we eat, and the information is assembled in the brain, which will identify whether we need to continue consuming or feel complete.
The participants dropped weight during the eight-week, low-calorie diet. The researchers concluded that individuals who lost even more weight in the year following the diet plan released more neurotensin than individuals who put on weight after completing the diet plan.
” It is a fascinating outcome. You can hypothesize whether the individuals who put on weight again just do not have the appetite-inhibiting impact which neurotensin appears to have,” says Signe Sørensen Torekov.
Studying cravings hormonal agents to discover how human beings may preserve weight reduction.
We understand that individuals who have undergone bariatric surgical treatment to reduce weight release more neurotensin when they consume. It was this insight that motivated the researchers to study the effect of neurotensin on weight loss.
” We know that other gut hormones, launched in greater quantities after weight problems surgical treatment, help explain why individuals who have actually gone through obesity surgical treatment are able to keep weight loss. But no one had studied the role of neurotensin in connection with diet-induced weight loss,” states MD and Ph.D. Student Joachim Holt, who is the very first author of the research study.
Whether a drug mimicing neurotensin release in the brain or intestines is interesting, describes Signe Sørensen Torekov.
” Another intriguing aspect of studying these hunger hormones is to find out how people might react to possible treatment and particularly the mix of numerous hunger hormonal agents to maintain weight reduction,” says Signe Sørensen Torekov.
When researchers very first found leptin, a crucial hormonal agent in weight policy, they discovered that quantities drop during weight loss. This could suggest that increasing the amount of leptin in the body would cause people to reduce weight.
” But it turns out that individuals who cope with obesity are leptin resistant, which implies that they do not react with weight reduction to the hormonal agent. We do not understand whether this likewise uses to neurotensin. We still have a lot of work ahead of us.”.
Referral: “Increased meal-induced neurotensin reaction forecasts effective maintenance of weight-loss– Data from a randomized controlled trial” by Annemette Overgaard Brethvad, Hannah Louise Zakariassen, Joachim Holt, Julie Rehné Lundgren, Alexander Jakobsen, Bolette Hartmann, Eva Winning Lehmann, Hannelouise Kissow, Jens Juul Holst, Sten Madsbad, Signe Sørensen Torekov and Birgitte Holst, 16 March 2023, Metabolism.DOI: 10.1016/ j.metabol.2023.155534.
” Initially, we analyzed the impact of weight loss in obese mice and concluded that weight loss led to reduced quantity of the hormone neurotensin. Subsequently, in a clinical study, we discovered that weight loss also led to a reduced amount of neurotensin in people. Remarkably, individuals who preserved weight loss released more neurotensin than people who gained back weight once again,” discusses Professor Signe Sørensen Torekov, who is the last author of the research study, at the Department of Biomedical Sciences at the University of Copenhagen.
” We know that other gut hormonal agents, released in greater amounts after weight problems surgery, help describe why individuals who have actually undergone weight problems surgical treatment are able to preserve weight loss. No one had actually studied the function of neurotensin in connection with diet-induced weight loss,” says MD and Ph.D.