” It is recognized that drugs alone are insufficient to lower the danger of heart disease in high blood pressure clients,” discussed Satoru Eguchi, MD, PhD, FAHA, Professor in the Cardiovascular Research Center, Sol Sherry Thrombosis Research Center, and Center for Metabolic Disease Research at the Lewis Katz School of Medicine at Temple University and senior investigator and co-corresponding author on the new study. “To help fix this issue, we became thinking about a supplement that could potentially reduce cardiovascular illness danger and started examining the results of bainiku-ekisu, an instilled juice concentrate of the Japanese plum.”
Ume fruit. Credit: Dr. Hirotoshi Utsunomiya
The infused juice concentrate, understood as bainiku-ekisu, has actually been consumed in Japan as a health supplement given that at least the 18th century. In experiments in smooth muscle cells of blood vessels, bainiku-ekisu was discovered to attenuate growth-promoting signals caused by angiotensin II– a circulatory hormone that plays a central function in the advancement of hypertension.
To better comprehend the possible anti-hypertensive results of bainiku-ekisu, Dr. Eguchi and Dr. Hirotoshi Utsunomiya, Professor in the Department of Rehabilitation at Osaka Kawasaki Rehabilitation University in Japan and co-corresponding author on the brand-new report, utilized a mouse model in which animals received infusions of angiotensin II to induce high blood pressure. Mice were then offered either plain water, in the control group, or water containing bainiku-ekisu.
Most especially, mice provided bainiku-ekisu did not establish high blood pressure, and in these animals tissue analysis showed that the juice concentrate safeguarded the vasculature from the effects of angiotensin II. Bainiku-ekisu likewise attenuated the infiltration of immune cells, which activate inflammatory processes associated with high blood pressure.
Dr. Eguchi and coworkers next checked out possible systems by which bainiku-ekisu prevented hypertension in mice. They looked particularly at molecular paths associated with glycolysis, the process by which cells breakdown glucose and which is a main feature of hypertension-induced hypertrophy.
” In high blood pressure, cells shift from aerobic metabolic process to glycolysis due to the fact that there is less oxygen offered in the cellular environment,” Dr. Eguchi explained. “This switch results in high levels of oxidative stress, which leads to more swelling, more vascular tightness, and, eventually, the development of more severe heart disease.” The groups experiments in cells showed that bainiku-ekisu avoids the switch to glycolysis, recommending that it secures versus angiotensin II-induced hypertension by alleviating hazardous metabolic modifications that underlie hypertrophy and swelling.
Dr. Eguchi and coworkers next plan to identify the particular compounds in bainiku-ekisu that are accountable for its protective impacts. “There might be 2 or three compounds working together, which might discuss why the infused juice concentrate of Ume is so popular as a health supplement,” Dr. Eguchi noted. “Multiple compounds collaborating would produce synergistic or additive impacts that may be lost in a pharmaceutical preparation.”
Recommendation: “Infused juice concentrate of Japanese plum Prunus mume attenuates inflammatory vascular remodeling in a mouse model of high blood pressure induced by angiotensin II” Keisuke Okuno, Keiichi Torimoto, Ryohei Kuroda, Stephanie M. Cicalese, Yoshiharu Okuno, Ryohei Kono, Shinsuke Marumoto, Hirotoshi Utsunomiya and Satoru Eguchi, 13 June 2023, Hypertension Research.DOI: 10.1038/ s41440-023-01332-9.
Other scientists who contributed to the brand-new study consist of Keisuke Okuno, Keiichi Torimoto, Ryohei Kuroda, and Stephanie M. Cicalese, Department of Cardiovascular Science, Lewis Katz School of Medicine at Temple University; Yoshiharu Okuno, National Institute of Technology, Wakayama College, Gobo, Japan; Ryohei Kono, Department of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka, Osaka, Japan; and Shinsuke Marumoto, Kindai University, Osaka, Japan.
The research was supported by the National Institutes of Health and by a research present fund from Kobayashi Pharmaceutical Japan.
A research study from Temple University suggests that bainiku-ekisu, a juice concentrate from the Japanese plum, might serve as an unique treatment for hypertension. In experiments in smooth muscle cells of blood vessels, bainiku-ekisu was discovered to attenuate growth-promoting signals induced by angiotensin II– a circulatory hormonal agent that plays a central function in the advancement of hypertension.
Most significantly, mice provided bainiku-ekisu did not develop hypertension, and in these animals tissue analysis suggested that the juice concentrate protected the vasculature from the effects of angiotensin II. Bainiku-ekisu likewise attenuated the infiltration of immune cells, which set off inflammatory processes associated with hypertension.
The teams experiments in cells showed that bainiku-ekisu avoids the switch to glycolysis, recommending that it protects versus angiotensin II-induced high blood pressure by mitigating hazardous metabolic modifications that underlie hypertrophy and swelling.
A research study from Temple University recommends that bainiku-ekisu, a juice concentrate from the Japanese plum, might serve as a novel treatment for high blood pressure. The research study showed that the juice secured against swelling and hypertrophy, reducing the threat of cardiovascular illness, a major concern for people with hypertension. The team is now determining the particular compounds responsible for these protective impacts.
Processed, infused juice concentrate revealed to have anti-hypertensive results in mice.
More than 122 million Americans– about half of the U.S. population ages 20 and older– have hypertension, referred to clinically as hypertension. High blood pressure is a major reason for heart disease, and despite advances in treatment, even clients who take medications to manage their blood pressure remain at high risk of death from illness like heart attack, cardiac arrest, and stroke.
The absence of new drugs to efficiently control high blood pressure and associated cardiovascular issues has actually fueled a search for unique treatment methods, and now, scientists at the Lewis Katz School of Medicine at Temple University have discovered a promising option. In brand-new work, the Temple scientists show that cardiovascular disease risk may be lowered with a simple juice concentrate from the Japanese plum (Prunus mume)– a fruit that is extensively consumed in Asian countries which is promoted as a health food in Japan. The new findings are described online in the journal Hypertension Research.
