The scientists found proof of socioeconomic, seasonal, and regional variations among numerous autoimmune conditions. Type 1 diabetes and vitiligo were more commonly detected in winter and summer, respectively. They suggested that such variations may indicate the participation of potentially modifiable threat elements such as cigarette smoking, stress, or obesity, contributing to the development of some autoimmune diseases.
The research study likewise revealed that individuals with one autoimmune disease were more most likely to develop a 2nd compared to those without an autoimmune illness.
” Autoimmune conditions are frequently associated with each other, especially Sjogrens, systemic lupus erythematosus, and systemic sclerosis,” said Nathalie Conrad from the Department of Public Health and Primary Care at KU Leuven in Belgium. “Patients with type 1 diabetes also have considerably greater rates of Addisons, coeliac, and thyroid diseases, and multiple sclerosis stands out as having low rates of co-occurrence with other autoimmune diseases.”
Not all autoimmune illness showed this pattern– numerous sclerosis, for example, stood out as having low rates of co-occurrence with other autoimmune diseases, suggesting a distinct pathophysiology.
These results suggest that the burden of autoimmune disease continues to increase with time, albeit modestly. One possible aspect might be that awareness for some conditions has actually increased over the study duration, alongside improved coding practices and earlier acknowledgment. Another possibility that might be inferred from the socioeconomic, seasonal, and local variations observed is that environmental factors might be linked in illness pathogenesis. The authors likewise conclude that the interrelations in between autoimmune illness point a finger at shared mechanisms or aspects.
Reference: “Incidence, occurrence, and co-occurrence of autoimmune disorders in time and by age, sex, and socioeconomic status: a population-based friend study of 22 million people in the UK” by Nathalie Conrad, Shivani Misra, Jan Y Verbakel, Geert Verbeke, Geert Molenberghs, Peter N Taylor, Justin Mason, Naveed Sattar, John J V McMurray, Iain B McInnes, Kamlesh Khunti and Geraldine Cambridge, 5 May 2023, The Lancet.DOI: 10.1016/ S0140-6736( 23 )00457-9.
Autoimmune illness represent a broad category of health conditions in which the bodys immune system wrongly attacks its own cells, tissues, or organs. Autoimmune diseases consist of conditions such as rheumatoid arthritis, lupus, and type 1 diabetes.
The research study utilized a vast dataset of anonymized electronic health records from the UK to examine 19 of the most common autoimmune diseases. Significantly, the age-standardized incidence rates of autoimmune diseases rose by 4% over the study period, with equivalent rates in both genders.
Autoimmune diseases represent a broad classification of health conditions in which the bodys body immune system wrongly assaults its own cells, tissues, or organs. This aberrant immune action can result in inflammation and damage to different parts of the body. Autoimmune illness include conditions such as rheumatoid arthritis, lupus, and type 1 diabetes.
Autoimmune conditions, where the body immune system mistakenly assaults healthy cells, now impact about one in 10 people, according to a brand-new population-based study of 22 million individuals.
The research study used a vast dataset of anonymized electronic health records from the UK to investigate 19 of the most common autoimmune diseases. The findings, which were released in The Lancet and presented at the 2023 EULAR congress in Milan, showed that these illness affect around 10% of the population– 13% of ladies and 7% of guys. This is higher than previous quotes, which often depend on smaller sample sizes and included less autoimmune conditions.
In between 2000 and 2019, a new diagnosis of one or more autoimmune illness was made in 978,872 individuals. Notably, the age-standardized occurrence rates of autoimmune illness rose by 4% over the study duration, with equal rates in both genders. The most significant boosts were observed in Graves illness, coeliac disease, and Sjogrens syndrome, the occurrences of which have actually doubled over the past twenty years. On the other hand, the occurrences of Hashimotos thyroiditis and pernicious anemia substantially reduced over the exact same duration.
