A current study performed by Lund University in Sweden raises concerns about the effectiveness of bariatric operations including gastric bypass. In this new study, which has actually been published in the journal Obesity, researchers carefully analyzed the metabolic process of overweight individuals both before and after undergoing a stomach bypass procedure.
The research study was based on information from 148 people with and without type 2 diabetes who went through a stomach bypass operation in Sweden. The study also revealed a reduction in the concentration of a particular type of amino acids after the operation and then a subsequent rise. A previous study by the same research team examined the impacts of a low-calorie diet plan and a gastric bypass operation independently.
A new study recommends that the most significant metabolic modifications after stomach bypass surgical treatment happen instantly post-operation, with many metabolic markers going back to pre-surgery levels within a year. Many patients experience initial weight loss and diabetes remission, these advantages may not be as lasting as formerly thought.
A recent research study carried out by Lund University in Sweden raises questions about the efficacy of bariatric operations including gastric bypass. According to the studys findings, the most significant metabolic changes take place right away following the surgery. Just one year post-operation, the levels of metabolites and fats in clients were observed to return to nearly the very same levels as before the treatment.
Earlier research has shown that most of gastric bypass patients experience weight restore within five years following the operation. The metabolic results of bariatric treatments on clients stay uncertain, as this aspect has actually not yet been conclusively established. In this new study, which has actually been released in the journal Obesity, scientists closely took a look at the metabolism of overweight individuals both before and after going through a stomach bypass treatment.
The research study shows that the most significant modifications happened directly after the procedure. One year later, the concentration of metabolites and fats amongst all the individuals was nearing the very same levels as before the operation.
” Just following up on the weight of people can be a blunt instrument for studying the results of the procedure. Our study offers a greater understanding of what happens to the metabolic process in connection with a gastric bypass operation,” states Peter Spégel, associate teacher of molecular metabolism at Lund University, who led the research study.
Quick modifications
The research study was based upon information from 148 people with and without type 2 diabetes who underwent a gastric bypass operation in Sweden. Blood samples were collected from participants right before the treatment and on at least 2 events after the operation. Their body mass index (BMI) was measured before the operation and on 3 occasions afterward.
The scientists conducted detailed analyses of fats and metabolites in the blood. Simply one year after the operation, a few of the individuals were back at exactly the very same levels as before the surgery, whereas the reversion was not as significant for others.
” We might see the changes while the participants still had a low BMI after the operation. By studying metabolic process, we can acquire a clear sign that unhealthy changes are on the way. We hope that the knowledge can be used in follow-up so that preventive procedures can be put in location,” says Nils Wierup, teacher of neuroendocrine cell biology at Lund University and one of the main authors of the short article.
Increased risk of type 2 diabetes
The levels of particular polyunsaturated fats increased straight after the operation to then fall and approach the very same levels as previously. Polyunsaturated fats are vital and can minimize the risk of cardiovascular disease. The research study likewise showed a reduction in the concentration of a specific kind of amino acids after the operation and after that a subsequent increase. The levels of these amino acids are usually high in individuals with insulin resistance and carry an increased threat of developing type 2 diabetes.
” One conclusion we draw is that the threat of developing type 2 diabetes is substantially minimized after the operation among individuals who do not have the disease, however one year later on we see an increased threat once again. Amongst people who currently had type 2 diabetes at the time of the surgery, we see a remission of the illness, however the danger of the disease returning then increases gradually,” states Peter Spégel.
The benefit of bariatric operations
Individuals who go through surgery for weight problems require to slim down before the operation by methods of a diet plan. A previous research study by the exact same research team analyzed the impacts of a gastric bypass and a low-calorie diet operation separately. The research study revealed that the diet plan had the most significant result on metabolism, whereas the surgical treatment led to rather little changes. The scientists newest study now shows that for many individuals, the positive impacts on metabolism decrease as quickly as one year later.
” We require more and bigger studies in order to draw trusted conclusions. One advantage of bariatric operations is that a bulk of individuals with type 2 diabetes see a remission of their illness afterward. And although a big percentage of people who undergo this procedure put on weight later, its generally not a return to the same weight as before. In the future, we wish to take a better look as what occurs to metabolic process on a specific level, as this can differ,” concludes Nils Wierup.
Recommendation: “Metabolic remission precedes possible weight gain back after stomach coronary bypass” by Oksana Rogova, Katharina Herzog, Mahmoud Al-Majdoub, Michael Miskelly, Andreas Lindqvist, Louise Bennet, Jan L. Hedenbro, Nils Wierup and Peter Spégel, 16 August 2023, Obesity.DOI: 10.1002/ oby.23864.