Polyphenols are a class of compounds discovered in lots of plant-based foods.” Polyphenols have many different impacts on the body and can be utilized to develop possible medications and health supplements,” Zhan stated. The poor water solubility and low bioavailability have actually restricted their health advantages, but by connecting sugar molecules, we can make them more soluble in water and steady.”
Zhans post sums up the different phenolic glycosides found in nature and the methods utilized to produce them.
” Polyphenols have several results on the body and can be utilized to develop possible medications and health supplements,” Zhan stated. “They likewise have natural preservative residential or commercial properties and can safeguard our body tissues from damage triggered by damaging substances. Regrettably, the poor water solubility and low bioavailability have actually restricted their health benefits, however by attaching sugar molecules, we can make them more soluble in water and stable.”
Professor Jixun Zhan. Credit: Matt Jensen/Utah State University
Researchers are utilizing new techniques, such as bacterial fermentation, to customize the sugar structures and glycosylation patterns of polyphenols. Zhans article summarizes the various phenolic glycosides found in nature and the methods used to produce them.
” By exploring the mechanisms behind the production of these compounds in bacteria and offering techniques for controling sugar biosynthesis, we can produce useful medical representatives and enhance lives,” Zhan said.
Different methods have been developed to produce polyphenolic glycosides in the laboratory, however a lot of are still at a little scale. Future research will concentrate on enhancing the effectiveness of production procedures, consisting of optimizing fermentation conditions and finding much better ways to carry the compounds.
” Polyphenolic glycosides are important compounds with diverse health benefits. Utilizing microorganisms to produce these substances in a economical and regulated way shows promise for massive production,” Zhan said.
Reference: “Engineered production of bioactive polyphenolic O-glycosides” by Jie Ren, Caleb Don Barton and Jixun Zhan, 5 April 2023, Biotechnology Advances.DOI: 10.1016/ j.biotechadv.2023.108146.
Scientists have actually found a way to enhance the health advantages of polyphenolic substances by making them water-soluble through glycosylation, paving the method for potentially life-saving drugs.
New research study indicates that combining polyphenolic compounds, which are typically found in veggies and fruits, with sugar molecules can lead to the advancement of potentially life-saving medications.
Polyphenols are a class of compounds found in numerous plant-based foods. Polyphenols assist avoid cellular damage in the body and can help prevent illness such as cancer or heart illness. Nevertheless, a lot of them do not liquify in water, making it challenging to completely benefit from their health benefits.
Biological Engineering Professor Jixun Zhan and his graduate students Jie Ren and Caleb Barton recently released a thorough review short article on crafted production of polyphenolic O-glycosides, which enable those polyphenolic compounds to remain stable and soluble through microbial fermentation. The research study was just recently published in the journal Biotechnology Advances.