New research found individual irregularity in gamma oscillations in the brain, previously believed to represent discomfort perception. This research study discovered these brain waves correspond within people however differ widely across people, leading the scientists to recommend a need for reviewing previous research study approaches.
A recent study has revealed that each individual possesses a distinct pain fingerprint in their brain, which can differ significantly from one individual to another. Led by the University of Essex, in partnership with the Ludwig Maximilians University of Munichs neuroscience of pain group, the research study determined that the fast oscillations in brain waves related to short discomfort and touch can vary commonly in scans.
Historically, these waves, called gamma oscillations, were believed to represent discomfort perception in the brain. However, earlier research primarily fixated collective information, often ignoring the differences observed in between people and in some cases even dismissing these variations as mere sound in the scans.
The Department of Psychologys Dr. Elia Valentini discovered major differences in timing, frequency, and area of the gamma oscillations and extremely some people revealed no waves at all.
In overall, information from 70 individuals were taken a look at. Overall, it was found that the topics gamma waves were “incredibly stable” and created similar individual patterns when stimulated.
We do not imply for gamma oscillations not to have a function in discomfort understanding, however we definitely will not discover its real function if we keep quantifying it as we did therefore far.”
An example of a gamma oscillation brain discomfort fingerprint. Credit: University of Essex
Dr Valentini said: “Not just, for the very first time, can we determine the severe variability in the gamma action throughout individuals, but we likewise show that the private action pattern is stable across time. This pattern of group variability and individual stability may use to other brain responses, and characterizing it might enable us to identify specific discomfort fingerprints in the activity of the brain.”
The study, released in the Journal of Neurophysiology, had the ability to map patterns in participants from another laboratory, suggesting a replicable phenomenon.
In total, information from 70 individuals were analyzed. The experiments were divided into two research studies with a laser utilized to create pain. In general, it was found that the topics gamma waves were “incredibly steady” and produced similar specific patterns when promoted.
Interestingly, some tape-recorded feeling discomfort and having no gamma response, whilst others had a large reaction.
Another gamma oscillation showing the person-to-person distinction. Credit: University of Essex
At this stage, it is not known why there is such variation– however it is hoped this will be a springboard for future research.
Dr Valentini added: “I think we need to go back to square one since previous findings on the relationship in between discomfort and gamma oscillations do not represent all the participants. This minority can drive the research results and lead to misleading conclusions about the functional significance of these responses. We do not suggest for gamma oscillations not to have a function in pain perception, but we certainly wont discover its real function if we keep measuring it as we did thus far.”
Dr. Valentini hopes this study will also change the method gamma oscillations are determined in other sensory domains.
Recommendation: “Interindividual variability and specific stability of pain- and touch-related neuronal gamma oscillations” by Elia Valentini, Alina Shindy, Viktor Witkovsky, Anne Stankewitz and Enrico Schulz, 6 June 2023, Journal of Neurophysiology.DOI: 10.1152/ jn.00530.2021.
