Scientist looked at self-reported liver cancer incidence and death due to chronic liver disease such as fibrosis, cirrhosis, or chronic hepatitis, which were more validated by medical records or the National Death Index.
More research studies are required to verify this danger association and figure out why sugary drinks appear to increase the danger of liver cancer and disease. Tobias reported grants from the National Cancer Institute (NCI) and grants from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK) during the conduct of the study.
Scientists from Brigham and Womens Hospital studied the link in between sugar-sweetened beverages and the danger of liver cancer and chronic liver illness mortality. The research study found that postmenopausal ladies taking in everyday sugar-sweetened drinks had a significantly higher danger of these liver-related outcomes compared to those consuming fewer beverages.
Around 65% of U.S. grownups consume sugar-sweetened beverages on an everyday basis.
Around 65% of American grownups regularly consume drinks sweetened with sugar. Chronic liver disease stands as a predominant source of health problem and death internationally, potentially leading to liver cancer and casualties connected with liver illness.
Scientists from Brigham and Womens Hospital, a founding member of the Mass General Brigham healthcare system, led one of the very first studies to take a look at the association in between intake of sugar-sweetened beverages, synthetically sweetened drinks, and the incidence of liver cancer and chronic liver illness death. The results of the study were recently released in the journal JAMA.
” To our understanding, this is the first study to report an association between sugar-sweetened drink consumption and chronic liver disease death,” stated very first author Longgang Zhao, Ph.D., of the Brighams Channing Division of Network Medicine. Zhao is a postdoctoral scientist who works with senior author Xuehong Zhang, MBBS, ScD, in the Channing Division. “Our findings, if verified, might lead the way to a public health strategy to reduce the danger of liver illness based on information from a geographically diverse and big friend.”
This observational study consisted of almost 100,000 postmenopausal women from the large, prospective Womens Health Initiative study. Researchers looked at self-reported liver cancer incidence and death due to persistent liver illness such as fibrosis, cirrhosis, or persistent hepatitis, which were more validated by medical records or the National Death Index.
A total of 98,786 postmenopausal women were included in the last analyses. The 6.8 percent of women who took in one or more sugar-sweetened beverages daily had an 85 percent higher threat of liver cancer and 68 percent greater danger of persistent liver disease mortality compared to those who had less than 3 sugar-sweetened beverages monthly.
The authors note that the study was observational, and causality can not be inferred and depended on self-reported responses about intake, sugar content, and results. More studies are needed to confirm this risk association and figure out why sugary drinks appear to increase the danger of liver cancer and illness. More research study is needed to elucidate the prospective systems by incorporating genes, preclinical and speculative research studies, and -omics data.
Referral: “Sugar-Sweetened and Artificially Sweetened Beverages and Risk of Liver Cancer and Chronic Liver Disease Mortality” by Longgang Zhao, Xinyuan Zhang, Mace Coday, David O. Garcia, Xinyi Li, Yasmin Mossavar-Rahmani, Michelle J. Naughton, Melissa Lopez-Pentecost, Nazmus Saquib, Aladdin H. Shadyab, Michael S. Simon, Linda G. Snetselaar, Fred K. Tabung, Deirdre K. Tobias, Trang VoPham, Katherine A. McGlynn, Howard D. Sesso, Edward Giovannucci, JoAnn E. Manson, Frank B. Hu, Lesley F. Tinker and Xuehong Zhang, JAMA.DOI: 10.1001/ jama.2023.12618.
Naughton reported grants from the National Institute of Aging (NIA) to The Ohio State University (to support the analysis and use of the Womens Health Initiative [WHI] data for numerous publications throughout the conduct of the research study; and grants from Merck Foundation (to support a research project not related to this article) outside the sent work. Tobias reported grants from the National Cancer Institute (NCI) and grants from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK) throughout the conduct of the study. VoPham reported personal costs from Georgetown University (speaker honorarium); and grants from NIH/NIDDK (K01 DK125612), NIH/NCI (P20 CA252732; P30 CA015704), and NIH/NHLBI (National Heart, Lung, and Blood Institute; 75N92019R0030) outside the sent work. Dr Manson reported grants from NIH throughout the conduct of the research study and grants from NIH and Mars Edge outside the sent work. No other disclosures were reported.
The Womens Health Initiative program is moneyed by the US Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600003C, hhsn268201600002c, and hhsn268201600004c. Zhang is supported by NIH/NCI grants (R21 CA238651, R21 CA252962, R37 CA262299, U01 CA259208, and U01 CA272452), an American Cancer Society Research Scholar Grant (RSG-17-190-01-NEC), and an American Cancer Society Interdisciplinary Team Award (PASD-22-1003396-01-PASD).
” To our understanding, this is the first research study to report an association in between sugar-sweetened beverage consumption and chronic liver illness death,” stated first author Longgang Zhao, Ph.D., of the Brighams Channing Division of Network Medicine. “Our findings, if confirmed, may pave the way to a public health technique to decrease the threat of liver disease based on data from a large and geographically varied mate.”