The research study was co-led by Dr. Valentín Fuster, CNIC General Director and Physician-in-Chief at Mount Sinai Medical Center in New York, and Dr. Borja Ibáñez, CNIC Scientific Director, a cardiologist at Hospital Universitario Fundación Jiménez Díaz, and a member of the CIBERCV cardiovascular research study network in Spain.
Progression of Subclinical Atherosclerosis.
Subclinical atherosclerosis typically advances in middle-aged individuals, especially if LDL-cholesterol levels and blood pressure are even slightly or reasonably raised. If risk factors are managed strongly from an early age, medical specialists and the general public requirement to be aware that atherosclerosis development can be stopped.
3-dimensional ultrasound reconstruction of a carotid artery in an apparently healthy PESA-CNIC-Santander study individual. The upper image shows the circumstance at the time of the very first imaging study, when no atherosclerotic plaques were found.
” Screening for subclinical atherosclerosis from an early age together with aggressive risk-factor control might help to decrease the global burden of heart disease,” stated Dr. Fuster.
Dr. Ibáñez discussed that “in this study, we reveal that moderate boosts in high blood pressure and cholesterol have a much more pronounced influence on atherosclerosis development in younger individuals.”.
Extremely few research studies have actually examined the development of quiet atherosclerosis in people who are completely devoid of symptoms, whether they are young or in obviously healthy middle-age, and how this disease advances throughout life.
The PESA-CNIC-Santander Study.
The PESA-CNIC-Santander research study (Progression of Early Subclinical Atherosclerosis) was launched in 2009 and is a close partnership in between the CNIC and Santander Bank. More than 4000 apparently healthy middle-aged Santander Bank staff members in Madrid offered to go through an extensive, noninvasive analysis of the carotid, femoral, and coronary arteries and the aorta. Participants likewise provided blood samples for sophisticated genomic, proteomic, and metabolomic analysis.
Representative results from participants revealing atherosclerosis progression (left) and regression (disappearance of plaques, right) in arteries of the neck (carotids) and groin (femorals). Each image set reveals the results of the preliminary study at standard and the follow-up study of the very same artery 6 years later on.
” The PESA study has actually currently made essential contributions to our understanding of heart disease and is considered the most innovative research study of its kind in the field,” said Dr. Fuster.
Implications for Prevention and Personalized Medicine.
The present findings have crucial ramifications for cardiovascular prevention and personalized medicine. The study shows that the control of threat elements (mainly raised cholesterol and high blood pressure) ought to begin early in life, when the arteries are more vulnerable to the effects of these danger elements.
And as Dr. Borja Ibáñez stressed, “These results point the way to customized approaches that utilize imaging innovation to keep an eye on the existence and progression of silent atherosclerosis and guide the intensity of risk-factor control.”.
Cardiologist Guiomar Mendieta, the very first author on the study, included that “the other key finding of this research study is that atherosclerosis, previously thought to be irreparable, can vanish if risk elements are controlled from an early phase.”.
” These findings are the outcome of the extensive collection of imaging and biochemical information over 6 years, integrated with an ingenious analytical analysis,” described Dr. Mendieta, who joined the CNIC through the CARDIOJOVEN SEC-CNIC training program, a joint effort of the CNIC and the Spanish Society of Cardiology.
Referral: “Determinants of Progression and Regression of Subclinical Atherosclerosis Over 6 Years” by Guiomar Mendieta, Stuart Pocock, Virginia Mass, Andrea Moreno, Ruth Owen, Inés García-Lunar, Beatriz López-Melgar, Jose J. Fuster, Vicente Andres, Cristina Pérez-Herreras, Hector Bueno, Antonio Fernández-Ortiz, Javier Sanchez-Gonzalez, Ana García-Alvarez, Borja Ibáñez and Valentin Fuster, 20 November 2023, Journal of the American College of Cardiology.DOI: 10.1016/ j.jacc.2023.09.814.
The CNIC detectives received funding from the European Commission, the Spanish Ministry of Science and Innovation, and the Community of Madrid regional federal government.
A brand-new research study exposes that young individuals are especially vulnerable to atherosclerosis from danger factors like high cholesterol and hypertension. Early and aggressive threat management is necessary to reverse or prevent atherosclerosis, as shown in the detailed PESA-CNIC-Santander research study. These findings are considerable for personalized cardiovascular prevention and treatment techniques.
Younger people are at a higher risk of experiencing the adverse cardiovascular impacts connected with raised blood cholesterol and high blood pressure.
Younger individuals may be more susceptible to the impacts of threat factors that can lead to atherosclerosis. Research study carried out by the Centro Nacional de Investigaciones Cardiovasculares (CNIC) shows that younger populations are particularly susceptible to the harmful repercussions of high blood cholesterol and high blood pressure, which are among the crucial flexible aspects influencing cardiovascular health.
These findings, released in the Journal of the American College of Cardiology, underline the need to carry out aggressive control of cardiovascular danger aspects at younger ages, requiring a modification in primary avoidance techniques to include “security of subclinical atherosclerosis and early cardiovascular danger aspect control.”.
By Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.).
November 27, 2023.
A new research study exposes that young individuals are particularly susceptible to atherosclerosis from risk factors like high cholesterol and high blood pressure. Early and aggressive threat management is vital to reverse or avoid atherosclerosis, as shown in the comprehensive PESA-CNIC-Santander research study. The PESA-CNIC-Santander research study (Progression of Early Subclinical Atherosclerosis) was launched in 2009 and is a close partnership in between the CNIC and Santander Bank. Representative results from individuals revealing atherosclerosis development (left) and regression (disappearance of plaques, right) in arteries of the neck (carotids) and groin (femorals). Each image set shows the outcomes of the initial research study at baseline and the follow-up research study of the very same artery 6 years later on.