Credit: SciTechDaily.com Research from Amsterdam shows that the sensations of fatigue in Long-COVID patients is causes by mitochondria that produce less energy.Scientists from Amsterdam UMC and Vrije Universiteit Amsterdam (VU) have discovered that the persistent fatigue in patients with long-COVID has a biological cause, specifically mitochondria in muscle cells that produce less energy than in healthy patients.” Were seeing clear modifications in the muscles in these patients,” says Michèle van Vugt, Professor of Internal Medicine at Amsterdam UMC.25 long-COVID patients and 21 healthy control participants took part in the study. The researchers looked at the blood and muscle tissue 1 week before the cycling test and 1 day after the test.Study Findings and Implications” We saw various abnormalities in the muscle tissue of the patients.
Credit: SciTechDaily.com Research from Amsterdam shows that the sensations of fatigue in Long-COVID clients is triggers by mitochondria that produce less energy.Scientists from Amsterdam UMC and Vrije Universiteit Amsterdam (VU) have found that the persistent fatigue in clients with long-COVID has a biological cause, namely mitochondria in muscle cells that produce less energy than in healthy patients.” Were seeing clear modifications in the muscles in these patients,” says Michèle van Vugt, Professor of Internal Medicine at Amsterdam UMC.25 long-COVID clients and 21 healthy control participants participated in the research study. The researchers looked at the blood and muscle tissue 1 week before the cycling test and 1 day after the test.Study Findings and Implications” We saw numerous problems in the muscle tissue of the patients. Signs in patients with long-COVID, post-acute sequelae or COVID or post-COVID syndrome (PCS) include extreme cognitive issues (brain fog), tiredness, exercise intolerance, autonomic dysregulation, postural orthostatic tachycardia syndrome (POTS), orthostatic intolerance, and worsening of symptoms after PEM.Reference: “Muscle irregularities intensify after post-exertional malaise in long COVID” by Brent Appelman, Braeden T. Charlton, Richie P. Goulding, Tom J. Kerkhoff, Ellen A. Breedveld, Wendy Noort, Carla Offringa, Frank W. Bloemers, Michel van Weeghel, Bauke V. Schomakers, Pedro Coelho, Jelle J. Posthuma, Eleonora Aronica, W. Joost Wiersinga, Michèle van Vugt and Rob C. I. Wüst, 4 January 2024, Nature Communications.DOI: 10.1038/ s41467-023-44432-3.