The information of this advancement are detailed in a publication in Cell Reports.The inherent immune system, important for defense versus infections, plays a key function in numerous diseases involving the immune system. The scientists have actually shown that sphingolipids can reprogram the memory of inherent immune cells, using new possibilities for treatment.The memory of natural immune cells, also known as experienced immunity, makes it possible for these cells to respond stronger and faster throughout reoccurring infections, an essential capability. Controling the sphingolipid balance in natural immune cells opens new possibilities for establishing therapies that can bring back the balance between effective defense and an overactive response.Reference: “Acid ceramidase controls natural immune memory” by Nils Rother, Cansu Yanginlar, Geoffrey Prévot, Inge Jonkman, Maaike Jacobs, Mandy M.T. van Leent, Julia van Heck, Vasiliki Matzaraki, Anthony Azzun, Judit Morla-Folch, Anna Ranzenigo, William Wang, Roy van der Meel, Zahi A. Fayad, Niels P. Riksen, Luuk B. Hilbrands, Rik G.H. Lindeboom, Joost H.A. Martens, Michiel Vermeulen, Leo A.B. Joosten, Mihai G. Netea, Willem J.M. Mulder, Johan van der Vlag, Abraham J.P. Teunissen and Raphaël Duivenvoorden, 22 November 2023, Cell Reports.DOI: 10.1016/ j.celrep.2023.113458.