Credit: SciTechDaily.comRecent research study highlights the dual function of VEGF-C-producing macrophages in breast growths, possibly assisting transition to less hazardous locations, opening new avenues for targeted cancer therapies.A brand-new study from Karolinska Institutet released in Cell reports shows that tumor-associated macrophages, which are white blood cells that are found in breast growths, can both assist and impede the spread of cancer cells to other organs. The researchers found that TAMs that reveal VEGF-C have a dual impact: they minimize the spread of breast cancer to the lungs however increase the spread to the lymph nodes at the same time.Clinical Implications and MechanismsThe scientists likewise analyzed this relationship in clinical information from clients with breast cancer. Understanding this procedure offers prospective insights for therapeutic interventions, perhaps by exploiting the paradox to prevent metastasis or redirect it to less harmful routes.Reference: “VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells” by Kaveri Banerjee, Thomas Kerzel, Tove Bekkhus, Sabrina de Souza Ferreira, Tatjana Wallmann, Majken Wallerius, Laura-Sophie Landwehr, Dennis Alexander Agardy, Nele Schauer, Anna Malmerfeldt, Jonas Bergh, Margarita Bartish, Johan Hartman, Arne Östman, Mario Leonardo Squadrito and Charlotte Rolny, 1 December 2023, Cell Reports.DOI: 10.1016/ j.celrep.2023.113507 The research study was primarily moneyed by the Swedish Research Council, the Swedish Cancer Society, and Radiumhemmets research study funds.
Credit: SciTechDaily.comRecent research study highlights the double function of VEGF-C-producing macrophages in breast tumors, potentially assisting transition to less harmful areas, opening new opportunities for targeted cancer therapies.A brand-new study from Karolinska Institutet released in Cell reports shows that tumor-associated macrophages, which are white blood cells that are found in breast tumors, can both assist and prevent the spread of cancer cells to other organs. The researchers found that TAMs that reveal VEGF-C have a dual effect: they lower the spread of breast cancer to the lungs however increase the spread to the lymph nodes at the same time.Clinical Implications and MechanismsThe researchers also analyzed this relationship in clinical data from clients with breast cancer. Understanding this process offers potential insights for healing interventions, possibly by making use of the paradox to prevent metastasis or reroute it to less damaging routes.Reference: “VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells” by Kaveri Banerjee, Thomas Kerzel, Tove Bekkhus, Sabrina de Souza Ferreira, Tatjana Wallmann, Majken Wallerius, Laura-Sophie Landwehr, Dennis Alexander Agardy, Nele Schauer, Anna Malmerfeldt, Jonas Bergh, Margarita Bartish, Johan Hartman, Arne Östman, Mario Leonardo Squadrito and Charlotte Rolny, 1 December 2023, Cell Reports.DOI: 10.1016/ j.celrep.2023.113507 The research study was primarily funded by the Swedish Research Council, the Swedish Cancer Society, and Radiumhemmets research study funds.