Researchers from the University of British Columbia have found a link between micronutrient deficiencies in early life and modifications in gut microbiomes, which may contribute to the increasing worldwide antibiotic resistance. The study stresses the need for comprehensive services to resolve undernutrition and its implications for antibiotic resistance.Researchers from the University of British Columbia have actually found significant links between early-life micronutrient shortages and gut microbiome composition, shedding light on the increasing international issue of antibiotic resistance.This research focused on comprehending the effect of inadequate levels of crucial micronutrients, including vitamin A, B12, folate, zinc, and iron, on the diverse range of germs, infections, fungi, and other bacteria residing in the digestive tract.Micronutrient Deficiencies and Antibiotic ResistanceThey discovered that these shortages led to considerable shifts in the gut microbiome of mice– most significantly a disconcerting expansion of bacteria and fungis known to be opportunistic pathogens.Importantly, mice with micronutrient deficiencies likewise showed a higher enrichment of genes that have actually been connected to antibiotic resistance. Resolving micronutrient shortages is about more than getting rid of malnutrition, it might likewise be a crucial action in fighting the worldwide scourge of antibiotic resistance.Reference: “Multiple micronutrient shortages in early life cause multi-kingdom changes in the gut microbiome and intrinsic antibiotic resistance genes in mice” by Paula T. Littlejohn, Avril Metcalfe-Roach, Erick Cardenas Poire, Ravi Holani, Haggai Bar-Yoseph, Yiyun M. Fan, Sarah E. Woodward and B. Brett Finlay, 16 November 2023, Nature Microbiology.DOI: 10.1038/ s41564-023-01519-3The research study was moneyed by the Canadian Institutes of Health Research.
