This research study, offering new insights into disease development and treatment, marks a considerable advance in understanding the interplay in between ancient genes and modern health.Researchers have actually produced the worlds largest ancient human gene bank by examining the bones and teeth of almost 5,000 people who lived throughout western Europe and Asia up to 34,000 years ago.By sequencing ancient human DNA and comparing it to modern-day samples, the global group of professionals mapped the historic spread of genes– and diseases– over time as populations migrated.The remarkable results have been revealed in 4 trailblazing research study documents just recently published in the very same issue of Nature and offer a new biological understanding of debilitating disorders.The remarkable research study involved a large worldwide team led by Professor Eske Willerslev at the Universities of Cambridge and Copenhagen, Professor Thomas Werge at the University of Copenhagen, and Professor Rasmus Nielsen at University of California, Berkeley, and included contributions from 175 researchers from around the globe.The researchers discovered: The stunning origins of neurodegenerative illness consisting of several sclerosisWhy northern Europeans today are taller than individuals from southern EuropeHow major migration around 5,000 years earlier presented risk genes into the population in north-western Europe– leaving a tradition of greater rates of MS todayCarrying the MS gene was an advantage at the time as it secured ancient farmers from capturing transmittable diseases from their sheep and cattleGenes understood to increase the risk of illness such as Alzheimers and type 2 diabetes were traced back to hunter-gatherersFuture analysis is hoped to reveal more about the genetic markers of autism, ADHD, schizophrenia, bipolar condition, and depressionNorthern Europe has the greatest occurrence of multiple sclerosis in the world.” Professor Astrid Iversen, another co-author based at the University of Oxford, said: “We now lead very various lives to those of our ancestors in terms of health, diet plan, and medical treatment options and this integrated with our evolutionary history implies we might be more vulnerable to certain illness than our ancestors were, including autoimmune illness such as MS.” The Lundbeck Foundation GeoGenetics Centre– the resource underpinning the discoveriesThe new findings were made possible by the analysis of information held in a special gene bank of ancient DNA, developed by the researchers over the past 5 years with financing from the Lundbeck Foundation.This is the very first gene bank of its kind in the world and currently it has actually allowed interesting new insights in areas from ancient human migrations, to genetically-determined threat profiles for the advancement of brain disorders.By evaluating the bones and teeth of nearly 5,000 ancient people, held in museum collections across Europe and Western Asia, the scientists generated DNA profiles varying across the Mesolithic and Neolithic through the Bronze Age, Iron Age and Viking duration into the Middle Ages.” Physical qualities and illness risks of modern-day Europeans” Its striking that the lifestyles of the individuals in the Eurasian region over the last 10,000 years have resulted in a hereditary tradition that affects their contemporary descendants, in terms of both their physical appearance and their risk of establishing a number of illness,” stated Dr. Evan Irving-Pease at The Globe Institute, University of Copenhagen, very first author of a separate Nature paper (The Selection Landscape and Genetic Legacy of Ancient Eurasians). North-Western Europeans carry more hereditary risk for numerous sclerosis, while Eastern Europeans have actually an increased hereditary threat of establishing Alzheimers and type 2 diabetes.Lactose tolerance: DNA analysis of the ancient residents of the Eurasia has exposed that lactose tolerance– the capability to digest the sugar in milk and other dairy items– emerged in Europe around 6,000 years ago.Vegetable tolerance: The capability to much better make it through on a vegetable-rich diet plan was composed into Europeans genes by the dawn of the Neolithic Age, around 5,900 years ago.Past human gene swimming pools of western EurasiaIn a third Nature paper, (Population Genomics of Postglacial Western Eurasia), the researchers, among which very first authors Morten Allentoft, professor at Curtin University, Australia and Lundbeck Foundation Geogenetics Centre at UCPH, Martin Sikora, associate professor at the Lundbeck Foundation Geogenetics Centre at UCPH, and Kristian Kristiansen, Professor of Archaeology at the University of Gothenburg, Sweden, reveal that genetic distinctions between ancient populations in western Eurasia were significantly higher than previously estimated, and likewise much higher than observed in present-day populations.Origins of modern-day DanesIn a 4th Nature paper, (( 100 Ancient Genomes Show Two Rapid Population Turnovers in Stone Age Denmark) the team reports findings that reverse the commonly-held view that the ancestors of present-day Danes were Stone Age hunter-gatherers. The Yamnaya individuals are the closest ancestors of contemporary ethnic Danes.Reference: “Elevated hereditary danger for multiple sclerosis emerged in steppe pastoralist populations” by William Barrie, Yaoling Yang, Evan K. Irving-Pease, Kathrine E. Attfield, Gabriele Scorrano, Lise Torp Jensen, Angelos P. Armen, Evangelos Antonios Dimopoulos, Aaron Stern, Alba Refoyo-Martinez, Alice Pearson, Abigail Ramsøe, Charleen Gaunitz, Fabrice Demeter, Marie Louise S. Jørkov, Stig Bermann Møller, Bente Springborg, Lutz Klassen, Inger Marie Hyldgård, Niels Wickmann, Lasse Vinner, Thorfinn Sand Korneliussen, Morten E. Allentoft, Martin Sikora, Kristian Kristiansen, Santiago Rodriguez, Rasmus Nielsen, Astrid K. N. Iversen, Daniel J. Lawson, Lars Fugger and Eske Willerslev, 10 January 2024, Nature.DOI: 10.1038/ s41586-023-06618-z” The selection landscape and hereditary tradition of ancient Eurasians” by Evan K. Irving-Pease, Alba Refoyo-Martínez, William Barrie, Andrés Ingason, Alice Pearson, Anders Fischer, Karl-Göran Sjögren, Alma S. Halgren, Ruairidh Macleod, Fabrice Demeter, Rasmus A. Henriksen, Tharsika Vimala, Hugh McColl, Andrew H. Vaughn, Leo Speidel, Aaron J. Stern, Gabriele Scorrano, Abigail Ramsøe, Andrew J. Schork, Anders Rosengren, Lei Zhao, Kristian Kristiansen, Astrid K. N. Iversen, Lars Fugger, Peter H. Sudmant, Daniel J. Lawson, Richard Durbin, Thorfinn Korneliussen, Thomas Werge, Morten E. Allentoft, Martin Sikora, Rasmus Nielsen, Fernando Racimo and Eske Willerslev, 10 January 2024, Nature.DOI: 10.1038/ s41586-023-06705-1″ Population genomics of post-glacial western Eurasia” by Morten E. Allentoft, Martin Sikora, Alba Refoyo-Martínez, Evan K. Irving-Pease, Anders Fischer, William Barrie, Andrés Ingason, Jesper Stenderup, Karl-Göran Sjögren, Alice Pearson, Bárbara Sousa da Mota, Bettina Schulz Paulsson, Alma Halgren, Ruairidh Macleod, Marie Louise Schjellerup Jørkov, Fabrice Demeter, Lasse Sørensen, Poul Otto Nielsen, Rasmus A. Henriksen, Tharsika Vimala, Hugh McColl, Ashot Margaryan, Melissa Ilardo, Andrew Vaughn, Morten Fischer Mortensen, Anne Birgitte Nielsen, Mikkel Ulfeldt Hede, Niels Nørkjær Johannsen, Peter Rasmussen, Lasse Vinner, Gabriel Renaud, Aaron Stern, Theis Zetner Trolle Jensen, Gabriele Scorrano, Hannes Schroeder, Per Lysdahl, Abigail Daisy Ramsøe, Andrei Skorobogatov, Andrew Joseph Schork, Anders Rosengren, Anthony Ruter, Alan Outram, Aleksey A. Timoshenko, Alexandra Buzhilova, Alfredo Coppa, Alisa Zubova, Ana Maria Silva, Anders J. Hansen, Andrey Gromov, Andrey Logvin, Anne Birgitte Gotfredsen, Bjarne Henning Nielsen, Borja González-Rabanal, Carles Lalueza-Fox, Catriona J. McKenzie, Charleen Gaunitz, Concepción Blasco, Corina Liesau, Cristina Martinez-Labarga, Dmitri V. Pozdnyakov, David Cuenca-Solana, David O. Lordkipanidze, Dmitri En shin, Domingo C. Salazar-García, T. Douglas Price, Dušan Borić, Elena Kostyleva, Elizaveta V. Veselovskaya, Emma R. Usmanova, Enrico Cappellini, Erik Brinch Petersen, Esben Kannegaard, Francesca Radina, Fulya Eylem Yediay, Henri Duday, Igor Gutiérrez-Zugasti, Ilya Merts, Inna Potekhina, Irina Shevnina, Isin Altinkaya, Jean Guilaine, Jesper Hansen, Joan Emili Aura Tortosa, João Zilhão, Jorge Vega, Kristoffer Buck Pedersen, Krzysztof Tunia, Lei Zhao, Liudmila N. Mylnikova, Lars Larsson, Laure Metz, Levon Yepiskoposyan, Lisbeth Pedersen, Lucia Sarti, Ludovic Orlando, Ludovic Slimak, Lutz Klassen, Malou Blank, Manuel González-Morales, Mara Silvestrini, Maria Vretemark, Marina S. Nesterova, Marina Rykun, Mario Federico Rolfo, Marzena Szmyt, Marcin Przybyła, Mauro Calattini, Mikhail Sablin, Miluše Dobisíková, Morten Meldgaard, Morten Johansen, Natalia Berezina, Nick Card, Nikolai A. Saveliev, Olga Poshekhonova, Olga Rickards, Olga V. Lozovskaya, Olivér Gábor, Otto Christian Uldum, Paola Aurino, Pavel Kosintsev, Patrice Courtaud, Patricia Ríos, Peder Mortensen, Per Lotz, Per Persson, Pernille Bangsgaard, Peter de Barros Damgaard, Peter Vang Petersen, Pilar Prieto Martinez, Piotr Włodarczak, Roman V. Smolyaninov, Rikke Maring, Roberto Menduiña, Ruben Badalyan, Rune Iversen, Ruslan Turin, Sergey Vasilyev, Sidsel Wåhlin, Svetlana Borutskaya, Svetlana Skochina, Søren Anker Sørensen, Søren H. Andersen, Thomas Jørgensen, Yuri B. Serikov, Vyacheslav I. Molodin, Vaclav Smrcka, Victor Merts, Vivek Appadurai, Vyacheslav Moiseyev, Yvonne Magnusson, Kurt H. Kjær, Niels Lynnerup, Daniel J. Lawson, Peter H. Sudmant, Simon Rasmussen, Thorfinn Sand Korneliussen, Richard Durbin, Rasmus Nielsen, Olivier Delaneau, Thomas Werge, Fernando Racimo, Kristian Kristiansen and Eske Willerslev, 10 January 2024, Nature.DOI: 10.1038/ s41586-023-06865-0″ 100 ancient genomes show repeated population turnovers in Neolithic Denmark” by Morten E. Allentoft, Martin Sikora, Anders Fischer, Karl-Göran Sjögren, Andrés Ingason, Ruairidh Macleod, Anders Rosengren, Bettina Schulz Paulsson, Marie Louise Schjellerup Jørkov, Maria Novosolov, Jesper Stenderup, T. Douglas Price, Morten Fischer Mortensen, Anne Birgitte Nielsen, Mikkel Ulfeldt Hede, Lasse Sørensen, Poul Otto Nielsen, Peter Rasmussen, Theis Zetner Trolle Jensen, Alba Refoyo-Martínez, Evan K. Irving-Pease, William Barrie, Alice Pearson, Bárbara Sousa da Mota, Fabrice Demeter, Rasmus A. Henriksen, Tharsika Vimala, Hugh McColl, Andrew Vaughn, Lasse Vinner, Gabriel Renaud, Aaron Stern, Niels Nørkjær Johannsen, Abigail Daisy Ramsøe, Andrew Joseph Schork, Anthony Ruter, Anne Birgitte Gotfredsen, Bjarne Henning Nielsen, Erik Brinch Petersen, Esben Kannegaard, Jesper Hansen, Kristoffer Buck Pedersen, Lisbeth Pedersen, Lutz Klassen, Morten Meldgaard, Morten Johansen, Otto Christian Uldum, Per Lotz, Per Lysdahl, Pernille Bangsgaard, Peter Vang Petersen, Rikke Maring, Rune Iversen, Sidsel Wåhlin, Søren Anker Sørensen, Søren H. Andersen, Thomas Jørgensen, Niels Lynnerup, Daniel J. Lawson, Simon Rasmussen, Thorfinn Sand Korneliussen, Kurt H. Kjær, Richard Durbin, Rasmus Nielsen, Olivier Delaneau, Thomas Werge, Kristian Kristiansen and Eske Willerslev, 10 January 2024, Nature.DOI: 10.1038/ s41586-023-06862-3.
Researchers developed the worlds biggest gene bank of ancient human DNA, studying remains from as much as 34,000 years ago to trace the spread of diseases and genes. Secret findings consist of the historical introduction of several sclerosis risk genes into Europe and the hereditary origins of neurodegenerative diseases. This research study, using brand-new insights into illness evolution and treatment, marks a significant advance in understanding the interplay between ancient genes and contemporary health.Researchers have produced the worlds biggest ancient human gene bank by examining the bones and teeth of nearly 5,000 humans who lived across western Europe and Asia as much as 34,000 years ago.By sequencing ancient human DNA and comparing it to modern-day samples, the global group of professionals mapped the historical spread of genes– and illness– gradually as populations migrated.The remarkable outcomes have been exposed in 4 trailblazing research documents recently published in the same problem of Nature and offer a brand-new biological understanding of crippling disorders.The extraordinary research study involved a large worldwide team led by Professor Eske Willerslev at the Universities of Cambridge and Copenhagen, Professor Thomas Werge at the University of Copenhagen, and Professor Rasmus Nielsen at University of California, Berkeley, and included contributions from 175 researchers from around the globe.The researchers found: The startling origins of neurodegenerative diseases consisting of multiple sclerosisWhy northern Europeans today are taller than individuals from southern EuropeHow major migration around 5,000 years ago introduced danger genes into the population in north-western Europe– leaving a legacy of greater rates of MS todayCarrying the MS gene was a benefit at the time as it protected ancient farmers from capturing infectious diseases from their sheep and cattleGenes understood to increase the danger of diseases such as Alzheimers and type 2 diabetes were traced back to hunter-gatherersFuture analysis is wanted to reveal more about the genetic markers of autism, ADHD, schizophrenia, bipolar affective disorder, and depressionNorthern Europe has the highest occurrence of several sclerosis in the world. A brand-new research study has actually found the genes that considerably increase a persons risk of developing several sclerosis (MS) were presented into north-western Europe around 5,000 years back by sheep and cattle herders moving from the east.Genetic History and DiseaseBy analyzing the DNA of ancient human bones and teeth, found at documented areas throughout Eurasia, scientists traced the geographical spread of MS from its origins on the Pontic Steppe (a region covering parts of what are now Ukraine, South-West Russia, and the West Kazakhstan Region). They found that the hereditary variations connected with a danger of establishing MS traveled with the Yamnaya individuals– livestock herders who moved over the Pontic Steppe into North-Western Europe.These genetic variations offered a survival advantage to the Yamnaya people, probably by safeguarding them from catching infections from their sheep and cattle. They also increased the danger of developing MS.” It must have been an unique benefit for the Yamnaya individuals to bring the MS threat genes, even after getting here in Europe, regardless of the truth that these genes unquestionably increased their risk of developing MS,” stated Professor Eske Willerslev, jointly at the Universities of Cambridge and Copenhagen and a Fellow of St Johns College, a specialist in analysis of ancient DNA and Director of the project.He added: “These outcomes alter our view of the causes of numerous sclerosis and have implications for the method it is treated.” The brand-new research study has actually found the genes that considerably increase an individuals danger of developing several sclerosis (MS) were presented into north-western Europe around 5,000 years ago by sheep and livestock herders moving from the east. Credit: SayoStudioThe age of specimens ranges from the Mesolithic and Neolithic through the Bronze Age, Iron Age, and Viking period into the Middle Ages. The earliest genome in the information set is from a person who lived approximately 34,000 years ago.The findings provide a description for the North-South Gradient, in which there are around twice as many modern-day cases of MS in northern Europe than southern Europe, which has long been a secret to researchers.From a genetic perspective, the Yamnaya people are thought to be the forefathers of the present-day residents of much of North-Western Europe. Their genetic impact on todays population of southern Europe is much weaker.Previous research studies have identified 233 genetic variations that increase the danger of establishing MS. These variations, also affected by environmental and lifestyle aspects, increase disease risk by around 30 percent. The new research found that this modern-day hereditary danger profile for MS is likewise present in bones and teeth that are thousands of years of ages.” These results astounded us all. They supply a substantial leap forward in our understanding of the evolution of MS and other autoimmune diseases. Demonstrating how the lifestyles of our forefathers impacted modern illness danger simply highlights just how much we are the recipients of ancient body immune systems in a modern-day world,” stated Dr William Barrie, a postdoc in the University of Cambridges Department of Zoology and co-author of the paper.Multiple sclerosis is a neurodegenerative illness in which the bodys body immune system incorrectly attacks the insulation surrounding the nerve fibers of the brain and spine cord. This causes symptom flares known as regressions as well as longer-term degeneration, known as progression.Professor Lars Fugger, a co-author of the MS study teacher and expert physician at John Radcliffe Hospital, University of Oxford, said: “This indicates we can now comprehend and seek to treat MS for what it really is: the result of a hereditary adjustment to particular ecological conditions that took place back in our prehistory.” Professor Astrid Iversen, another co-author based at the University of Oxford, stated: “We now lead really different lives to those of our forefathers in terms of hygiene, diet plan, and medical treatment choices and this integrated with our evolutionary history indicates we may be more susceptible to specific illness than our forefathers were, consisting of autoimmune diseases such as MS.” The Lundbeck Foundation GeoGenetics Centre– the resource underpinning the discoveriesThe brand-new findings were enabled by the analysis of information kept in a distinct gene bank of ancient DNA, developed by the researchers over the past 5 years with financing from the Lundbeck Foundation.This is the first gene bank of its kind on the planet and currently it has actually made it possible for fascinating new insights in locations from ancient human migrations, to genetically-determined danger profiles for the development of brain disorders.By analysing the bones and teeth of almost 5,000 ancient people, kept in museum collections across Europe and Western Asia, the researchers generated DNA profiles ranging throughout the Mesolithic and Neolithic through the Bronze Age, Iron Age and Viking period into the Middle Ages. They compared the ancient DNA information to contemporary DNA from 400,000 people living in Britain, kept in the UK Biobank.” Creating a gene bank of ancient DNA from Eurasias previous human residents was a colossal task, including partnership with museums throughout the region,” stated Willerslev.He included: “Weve demonstrated that our gene bank works as a precision tool that can give us brand-new insights into human diseases, when combined with analyses of contemporary human DNA data and inputs from several other research study fields. That in itself is remarkable, and theres no doubt it has numerous applications beyond MS research study.” The team now plans to examine other neurological conditions including Parkinsons and Alzheimers illness, and psychiatric conditions consisting of ADHD and schizophrenia.They have actually gotten demands from illness scientists throughout the world for access to the ancient DNA profiles, and ultimately objective to make the gene bank open access.The research study was moneyed by a EUR8M grant from the Lundbeck Foundation, and conducted at the Lundbeck Foundation Geogenetics Centre at the University of Copenhagen.Jan Egebjerg, Director of Research at the Lundbeck Foundation, stated: “The reasoning for awarding such a big research study grant to this job, as the Lundbeck Foundation did back in 2018, was that if all of it worked out, it would represent a trail-blazing means of getting a much deeper understanding of how the hereditary architecture underlying brain conditions evolved gradually. And brain conditions are our particular focus location.” Physical characteristics and disease threats of modern-day Europeans” Its striking that the way of lives of the individuals in the Eurasian area over the last 10,000 years have actually resulted in a hereditary legacy that impacts their present-day descendants, in regards to both their physical appearance and their danger of developing a variety of illness,” said Dr. Evan Irving-Pease at The Globe Institute, University of Copenhagen, first author of a different Nature paper (The Selection Landscape and Genetic Legacy of Ancient Eurasians). By comparing DNA from 1,664 historical skeletons of the ancient occupants of the Eurasia– varying in age from the Mesolithic (Middle Stone Age) to around 1,000 BC– to over 400,000 DNA profiles from contemporary Europeans, the team has gained a host of new insights into our genetic histories, consisting of: Body height: North-Western Europeans today are normally taller than Southern Europeans– a genetic predisposition to being tall is likely to have originated from the Yamnaya.Disease danger: Influenced by just how much DNA an individual has from the ancient populations that moved throughout Eurasia after the last Ice Age. For instance, Southern Europeans generally have a great deal of ancient farmer DNA and are genetically inclined to establishing bipolar condition. North-Western Europeans bring more hereditary danger for numerous sclerosis, while Eastern Europeans have an increased hereditary risk of establishing Alzheimers and type 2 diabetes.Lactose tolerance: DNA analysis of the ancient residents of the Eurasia has revealed that lactose tolerance– the capability to absorb the sugar in milk and other dairy products– emerged in Europe around 6,000 years ago.Vegetable tolerance: The ability to much better make it through on a vegetable-rich diet plan was written into Europeans genes by the dawn of the Neolithic Age, around 5,900 years ago.Past human gene swimming pools of western EurasiaIn a 3rd Nature paper, (Population Genomics of Postglacial Western Eurasia), the scientists, amongst which very first authors Morten Allentoft, professor at Curtin University, Australia and Lundbeck Foundation Geogenetics Centre at UCPH, Martin Sikora, associate professor at the Lundbeck Foundation Geogenetics Centre at UCPH, and Kristian Kristiansen, Professor of Archaeology at the University of Gothenburg, Sweden, reveal that genetic differences in between ancient populations in western Eurasia were substantially greater than formerly estimated, and also much higher than observed in present-day populations.Origins of modern-day DanesIn a fourth Nature paper, (( 100 Ancient Genomes Show Two Rapid Population Turnovers in Stone Age Denmark) the group reports findings that overturn the commonly-held view that the ancestors of contemporary Danes were Stone Age hunter-gatherers. The group, which consists of Prof. Kristian Kristiansen and Dr. Anders Fischer, both of whom are associated with the Lundbeck Foundation Geogenetics Centre at the University of Copenhagen (UCPH), analyzed DNA from 100 skeletons of the prehistoric occupants of the area now understood as Denmark, who lived between 10,000 years ago and 2,700 years ago.They found that given that the last Ice Age around 12,000 years earlier, Denmark has actually experienced two near-total population turnover occasions, the second of which is still evident in the gene pool of present-day Scandinavia.Around 5,900 years ago at the dawn of the Neolithic Age, a group of farmers with genetic roots in Anatolia– the Asian part of contemporary Turkey– brought a brand-new farming culture to Denmark. The resulting changes in diet plan were clear in analysis of the ancient bones, and show that these farmers completely changed the hunter-gatherers residing in the region.Then, around 5,000 years earlier, the Yamnaya showed up and eliminated the Anatolian farmers. The Yamnaya people are the closest forefathers of present-day ethnic Danes.Reference: “Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations” by William Barrie, Yaoling Yang, Evan K. Irving-Pease, Kathrine E. Attfield, Gabriele Scorrano, Lise Torp Jensen, Angelos P. Armen, Evangelos Antonios Dimopoulos, Aaron Stern, Alba Refoyo-Martinez, Alice Pearson, Abigail Ramsøe, Charleen Gaunitz, Fabrice Demeter, Marie Louise S. Jørkov, Stig Bermann Møller, Bente Springborg, Lutz Klassen, Inger Marie Hyldgård, Niels Wickmann, Lasse Vinner, Thorfinn Sand Korneliussen, Morten E. Allentoft, Martin Sikora, Kristian Kristiansen, Santiago Rodriguez, Rasmus Nielsen, Astrid K. N. Iversen, Daniel J. Lawson, Lars Fugger and Eske Willerslev, 10 January 2024, Nature.DOI: 10.1038/ s41586-023-06618-z” The selection landscape and genetic legacy of ancient Eurasians” by Evan K. Irving-Pease, Alba Refoyo-Martínez, William Barrie, Andrés Ingason, Alice Pearson, Anders Fischer, Karl-Göran Sjögren, Alma S. Halgren, Ruairidh Macleod, Fabrice Demeter, Rasmus A. Henriksen, Tharsika Vimala, Hugh McColl, Andrew H. Vaughn, Leo Speidel, Aaron J. Stern, Gabriele Scorrano, Abigail Ramsøe, Andrew J. Schork, Anders Rosengren, Lei Zhao, Kristian Kristiansen, Astrid K. N. Iversen, Lars Fugger, Peter H. Sudmant, Daniel J. Lawson, Richard Durbin, Thorfinn Korneliussen, Thomas Werge, Morten E. Allentoft, Martin Sikora, Rasmus Nielsen, Fernando Racimo and Eske Willerslev, 10 January 2024, Nature.DOI: 10.1038/ s41586-023-06705-1″ Population genomics of post-glacial western Eurasia” by Morten E. Allentoft, Martin Sikora, Alba Refoyo-Martínez, Evan K. Irving-Pease, Anders Fischer, William Barrie, Andrés Ingason, Jesper Stenderup, Karl-Göran Sjögren, Alice Pearson, Bárbara Sousa da Mota, Bettina Schulz Paulsson, Alma Halgren, Ruairidh Macleod, Marie Louise Schjellerup Jørkov, Fabrice Demeter, Lasse Sørensen, Poul Otto Nielsen, Rasmus A. Henriksen, Tharsika Vimala, Hugh McColl, Ashot Margaryan, Melissa Ilardo, Andrew Vaughn, Morten Fischer Mortensen, Anne Birgitte Nielsen, Mikkel Ulfeldt Hede, Niels Nørkjær Johannsen, Peter Rasmussen, Lasse Vinner, Gabriel Renaud, Aaron Stern, Theis Zetner Trolle Jensen, Gabriele Scorrano, Hannes Schroeder, Per Lysdahl, Abigail Daisy Ramsøe, Andrei Skorobogatov, Andrew Joseph Schork, Anders Rosengren, Anthony Ruter, Alan Outram, Aleksey A. Timoshenko, Alexandra Buzhilova, Alfredo Coppa, Alisa Zubova, Ana Maria Silva, Anders J. Hansen, Andrey Gromov, Andrey Logvin, Anne Birgitte Gotfredsen, Bjarne Henning Nielsen, Borja González-Rabanal, Carles Lalueza-Fox, Catriona J. McKenzie, Charleen Gaunitz, Concepción Blasco, Corina Liesau, Cristina Martinez-Labarga, Dmitri V. Pozdnyakov, David Cuenca-Solana, David O. Lordkipanidze, Dmitri En shin, Domingo C. Salazar-García, T. Douglas Price, Dušan Borić, Elena Kostyleva, Elizaveta V. Veselovskaya, Emma R. Usmanova, Enrico Cappellini, Erik Brinch Petersen, Esben Kannegaard, Francesca Radina, Fulya Eylem Yediay, Henri Duday, Igor Gutiérrez-Zugasti, Ilya Merts, Inna Potekhina, Irina Shevnina, Isin Altinkaya, Jean Guilaine, Jesper Hansen, Joan Emili Aura Tortosa, João Zilhão, Jorge Vega, Kristoffer Buck Pedersen, Krzysztof Tunia, Lei Zhao, Liudmila N. Mylnikova, Lars Larsson, Laure Metz, Levon Yepiskoposyan, Lisbeth Pedersen, Lucia Sarti, Ludovic Orlando, Ludovic Slimak, Lutz Klassen, Malou Blank, Manuel González-Morales, Mara Silvestrini, Maria Vretemark, Marina S. Nesterova, Marina Rykun, Mario Federico Rolfo, Marzena Szmyt, Marcin Przybyła, Mauro Calattini, Mikhail Sablin, Miluše Dobisíková, Morten Meldgaard, Morten Johansen, Natalia Berezina, Nick Card, Nikolai A. Saveliev, Olga Poshekhonova, Olga Rickards, Olga V. Lozovskaya, Olivér Gábor, Otto Christian Uldum, Paola Aurino, Pavel Kosintsev, Patrice Courtaud, Patricia Ríos, Peder Mortensen, Per Lotz, Per Persson, Pernille Bangsgaard, Peter de Barros Damgaard, Peter Vang Petersen, Pilar Prieto Martinez, Piotr Włodarczak, Roman V. Smolyaninov, Rikke Maring, Roberto Menduiña, Ruben Badalyan, Rune Iversen, Ruslan Turin, Sergey Vasilyev, Sidsel Wåhlin, Svetlana Borutskaya, Svetlana Skochina, Søren Anker Sørensen, Søren H. Andersen, Thomas Jørgensen, Yuri B. Serikov, Vyacheslav I. Molodin, Vaclav Smrcka, Victor Merts, Vivek Appadurai, Vyacheslav Moiseyev, Yvonne Magnusson, Kurt H. Kjær, Niels Lynnerup, Daniel J. Lawson, Peter H. Sudmant, Simon Rasmussen, Thorfinn Sand Korneliussen, Richard Durbin, Rasmus Nielsen, Olivier Delaneau, Thomas Werge, Fernando Racimo, Kristian Kristiansen and Eske Willerslev, 10 January 2024, Nature.DOI: 10.1038/ s41586-023-06865-0″ 100 ancient genomes show duplicated population turnovers in Neolithic Denmark” by Morten E. Allentoft, Martin Sikora, Anders Fischer, Karl-Göran Sjögren, Andrés Ingason, Ruairidh Macleod, Anders Rosengren, Bettina Schulz Paulsson, Marie Louise Schjellerup Jørkov, Maria Novosolov, Jesper Stenderup, T. Douglas Price, Morten Fischer Mortensen, Anne Birgitte Nielsen, Mikkel Ulfeldt Hede, Lasse Sørensen, Poul Otto Nielsen, Peter Rasmussen, Theis Zetner Trolle Jensen, Alba Refoyo-Martínez, Evan K. Irving-Pease, William Barrie, Alice Pearson, Bárbara Sousa da Mota, Fabrice Demeter, Rasmus A. Henriksen, Tharsika Vimala, Hugh McColl, Andrew Vaughn, Lasse Vinner, Gabriel Renaud, Aaron Stern, Niels Nørkjær Johannsen, Abigail Daisy Ramsøe, Andrew Joseph Schork, Anthony Ruter, Anne Birgitte Gotfredsen, Bjarne Henning Nielsen, Erik Brinch Petersen, Esben Kannegaard, Jesper Hansen, Kristoffer Buck Pedersen, Lisbeth Pedersen, Lutz Klassen, Morten Meldgaard, Morten Johansen, Otto Christian Uldum, Per Lotz, Per Lysdahl, Pernille Bangsgaard, Peter Vang Petersen, Rikke Maring, Rune Iversen, Sidsel Wåhlin, Søren Anker Sørensen, Søren H. Andersen, Thomas Jørgensen, Niels Lynnerup, Daniel J. Lawson, Simon Rasmussen, Thorfinn Sand Korneliussen, Kurt H. Kjær, Richard Durbin, Rasmus Nielsen, Olivier Delaneau, Thomas Werge, Kristian Kristiansen and Eske Willerslev, 10 January 2024, Nature.DOI: 10.1038/ s41586-023-06862-3.
