Medulloblastoma represents one of the most extreme and common brain tumors in kids, stemming from primitive cells in the early phases of neural development.A study led by a group of Brazilian researchers has shown in vitro and in vivo that the gene VAPB is linked to cell expansion in these growths. On the other hand, we discovered that high expression of VAPB in medulloblastoma associated with a reduction in patient survival, and when we got rid of the expression of the protein in growth cells, the cellular cycle slowed but the cells did not die. The controls were neural progenitor cells obtained from a line of human induced pluripotent stem cells (hiPSCs).” Although VAPB is not generally linked to cancer, we detected changes to numerous pathways classically studied in tumors in the VAPB-knockout cells. In my view, this finding will promote research on other proteins as they pertain to types of cancer for which ideal treatments do not yet exist,” Assoni said.An earlier research study utilizing laboratory-cultured cell lines, led by Okamoto and released in the journal Brain Research in 2020, determined molecules, consisting of the protein OCT4, with the possible to serve as medulloblastoma biomarkers.
Medulloblastoma represents one of the most severe and widespread brain growths in children, stemming from primitive cells in the early phases of neural development.A research study led by a group of Brazilian researchers has revealed in vitro and in vivo that the gene VAPB is linked to cell proliferation in these growths. On the other hand, we discovered that high expression of VAPB in medulloblastoma correlated with a decrease in client survival, and when we removed the expression of the protein in growth cells, the cellular cycle slowed however the cells did not die. The controls were neural progenitor cells obtained from a line of human induced pluripotent stem cells (hiPSCs).