Credit: University of Dundee”The glue that we have actually been able to define is unique due to the fact that it initially attaches itself to one protein in two locations– not just one– and then recruits the second protein, efficiently sandwiching the 2 proteins together.”Advancing Targeted Protein DegradationTargeted protein deterioration (TPD) is an emerging field of drug development for treating illness that involves rerouting protein recycling systems in our cells to damage disease-causing proteins. The E3 tags the target protein with ubiquitin labels, which ultimately leads to the destruction of the disease-causing protein by means of the cellular waste bin: the proteasome.Working with collaborators at CEMM, the Goethe University of Frankfurt, and Eisai Co. Ltd, the Japanese pharmaceutical business, the Dundee team has actually been able to reveal an unique mechanism of molecular gluing, different from those previously understood.
Credit: University of Dundee”The glue that we have been able to define is special due to the fact that it first attaches itself to one protein in two locations– not simply one– and then hires the second protein, efficiently sandwiching the 2 proteins together.”Advancing Targeted Protein DegradationTargeted protein degradation (TPD) is an emerging field of drug development for dealing with diseases that involves redirecting protein recycling systems in our cells to ruin disease-causing proteins. The E3 tags the target protein with ubiquitin labels, which ultimately leads to the damage of the disease-causing protein through the cellular waste bin: the proteasome.Working with partners at CEMM, the Goethe University of Frankfurt, and Eisai Co. Ltd, the Japanese pharmaceutical business, the Dundee group has been able to unveil an unique system of molecular gluing, different from those previously understood.