The artists impression shows how the HIV capsid permeates the jelly-like permeability barrier of a nuclear pore. Picked proteins can pass due to the fact that the barrier is not hermetically sealed.Thousands of small nuclear pores in the nuclear envelope offer a passageway. The HIV capsid can hence go into the nuclear pore without assisting transporters and bypass the protective mechanism that otherwise avoids viruses from invading the cell nucleus,” the biochemist explains.His group has actually prospered in replicating FG phases in the laboratory.” In one regard the HIV capsid varies fundamentally from formerly studied transporters that pass nuclear pores: It encapsulates its freight completely and thus conceals its genomic payload from anti-viral sensors in the cytoplasm. The observation that the capsid is an importin-like transporter might one day be exploited for much better AIDS therapies.Reference: “HIV-1 capsids go into the FG phase of nuclear pores like a transport receptor” by Liran Fu, Erika N. Weiskopf, Onno Akkermans, Nicholas A. Swanson, Shiya Cheng, Thomas U. Schwartz and Dirk Görlich, 24 January 2024, Nature.DOI: 10.1038/ s41586-023-06966-w.
Picked proteins can pass because the barrier is not hermetically sealed.Thousands of small nuclear pores in the nuclear envelope supply a passage. The HIV capsid can hence enter the nuclear pore without helping transporters and bypass the protective system that otherwise avoids infections from invading the cell nucleus,” the biochemist explains.His team has succeeded in recreating FG stages in the laboratory. The observation that the capsid is an importin-like transporter may one day be made use of for much better AIDS therapies.Reference: “HIV-1 capsids get in the FG phase of nuclear pores like a transport receptor” by Liran Fu, Erika N. Weiskopf, Onno Akkermans, Nicholas A. Swanson, Shiya Cheng, Thomas U. Schwartz and Dirk Görlich, 24 January 2024, Nature.DOI: 10.1038/ s41586-023-06966-w.
