— Professor Jakob Nilsson” We were extremely surprised to find that SARS-CoV-2 hijacks proteins associated with Fragile X Syndrome, which is the most typical hereditary cause of intellectual impairment,” Jakob Nilsson says.To further check out the connection in between coronavirus and the Fragile X-related proteins, Postdoc Dimitriya Garvanska, who did the lab work, utilized numerous cell-biological and biochemical techniques to comprehend the process.The group desired to know whether pirating the Fragile X-related proteins was important to the virus capability to spread through the body.” This recommends that we need to perhaps be more attentive to these patients,” Jakob Nilsson says.The research study supplies insight into the possible cause of Fragile X SyndromeAside from recognizing the connection in between coronavirus and Fragile X Syndrome, Jakob Nilsson, Dimitriya Garvanska and their colleagues likewise gained a deeper understanding of Fragile X Syndrome. Generally, the more insight we acquire into these systems, the better are our chances of impacting them in the future,” Jakob Nilsson concludes.You can check out the study “SARS-CoV-2 pirates delicate X psychological retardation proteins for effective infection” in EMBO Reports.Reference: “The NSP3 protein of SARS-CoV-2 binds fragile X psychological retardation proteins to disrupt UBAP2L interactions” by Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M Mc Leland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery and Jakob Nilsson, 2 January 2024, EMBO Reports.DOI: 10.1038/ s44319-023-00043-z.
A new research study exposes how the coronavirus SARS-CoV-2 interacts with Fragile X-related proteins, impacting its spread and suggesting increased vulnerability for people with Fragile X Syndrome.– Professor Jakob Nilsson” We were incredibly shocked to find that SARS-CoV-2 hijacks proteins associated with Fragile X Syndrome, which is the most typical hereditary cause of intellectual disability,” Jakob Nilsson says.To even more explore the connection between coronavirus and the Fragile X-related proteins, Postdoc Dimitriya Garvanska, who did the laboratory work, used different cell-biological and biochemical techniques to understand the process.The group wanted to know whether hijacking the Fragile X-related proteins was crucial to the virus capability to spread through the body.” This recommends that we ought to perhaps be more attentive to these patients,” Jakob Nilsson says.The research study provides insight into the possible cause of Fragile X SyndromeAside from identifying the connection in between coronavirus and Fragile X Syndrome, Jakob Nilsson, Dimitriya Garvanska and their associates also got a much deeper understanding of Fragile X Syndrome. Essentially, the more insight we get into these systems, the much better are our possibilities of affecting them in the future,” Jakob Nilsson concludes.You can check out the research study “SARS-CoV-2 pirates vulnerable X psychological retardation proteins for efficient infection” in EMBO Reports.Reference: “The NSP3 protein of SARS-CoV-2 binds vulnerable X mental retardation proteins to interrupt UBAP2L interactions” by Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M Mc Leland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery and Jakob Nilsson, 2 January 2024, EMBO Reports.DOI: 10.1038/ s44319-023-00043-z.