Conversely, inhibiting the function of the inceptor might enhance insulin signaling– which in turn is required for overall beta cell function, survival, and compensation upon stress.In cooperation with Prof. Timo Müller, an expert in molecular pharmacology in weight problems and diabetes, the scientists explored the impacts of inceptor knock-out in diet-induced overweight mice. Ultimately, the researchers selectively got rid of the inceptor from the mices beta cells, resulting in enhanced glucose control and a small boost in beta cell mass.Research for Inceptor-Blocking Drugs” Our findings support the idea that boosting insulin sensitivity through targeting inceptor reveals guarantee as a pharmacological intervention, especially concerning the health and function of beta cells,” says Timo Müller. Looking forward, inceptor emerges as a novel and appealing molecular target for enhancing beta cell health, not just in prediabetic obese people but also in patients identified with type 2 diabetes,” discusses Heiko Lickert.Reference: “Global, neuronal or β cell-specific removal of inceptor improves glucose homeostasis in male mice with diet-induced obesity” by Gerald Grandl, Gustav Collden, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina Garcia-Caceres, Annette Feuchtinger, Matthias H. Tschöp, Natalie Krahmer, Heiko Lickert and Timo D. Müller, 28 February 2024, Nature Metabolism.DOI: 10.1038/ s42255-024-00991-3.
On the other hand, preventing the function of the inceptor might boost insulin signaling– which in turn is needed for general beta cell function, survival, and settlement upon stress.In partnership with Prof. Timo Müller, a specialist in molecular pharmacology in obesity and diabetes, the researchers checked out the results of inceptor knock-out in diet-induced overweight mice. The results were now published in Nature Metabolism.Removing Inceptor Improves Blood Sugar Levels in Obese MiceThe scientists dug into the results of getting rid of inceptor from all body cells in diet-induced overweight mice. Eventually, the researchers selectively eliminated the inceptor from the mices beta cells, resulting in improved glucose control and a minor increase in beta cell mass.Research for Inceptor-Blocking Drugs” Our findings support the concept that improving insulin level of sensitivity through targeting inceptor shows pledge as a medicinal intervention, especially concerning the health and function of beta cells,” states Timo Müller. Looking forward, inceptor emerges as a appealing and novel molecular target for improving beta cell health, not just in prediabetic obese individuals but likewise in patients diagnosed with type 2 diabetes,” explains Heiko Lickert.Reference: “Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity” by Gerald Grandl, Gustav Collden, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina Garcia-Caceres, Annette Feuchtinger, Matthias H. Tschöp, Natalie Krahmer, Heiko Lickert and Timo D. Müller, 28 February 2024, Nature Metabolism.DOI: 10.1038/ s42255-024-00991-3.