Research study suggests a cell surface area protein, known for spotting odors, may be essential to comprehending why high blood pressure differs in between sexes, resulting in prospective modifications in how blood pressure is dealt with for men and women.Johns Hopkins Medicine researchers found that a protein receptor associated with picking up odors might describe sex distinctions in blood pressure.Using information from both people and mice, a Johns Hopkins Medicine research study group has discovered that a cell surface protein that senses odors and chemicals might be responsible for– and help describe– sex differences in mammalian blood pressure. The uncommon connection in between such protein receptors and sex distinctions in high blood pressure, reported in the March 20 problem of Science Advances, might result in a much better understanding of long-known distinctions in high blood pressure in between women and males.Scientific Investigation Into Olfactory ReceptorsBlood pressure in premenopausal human and mouse females is generally 10 points lower in both systolic and diastolic pressure than in males. Some research studies suggest the difference may be triggered by sex hormones, but the biological basis for the variation is not totally clear.”Despite the popular differences in blood pressure in between males and women, many medical standards have the same thresholds for treatment,” states Jennifer Pluznick, Ph.D., associate professor of physiology at the Johns Hopkins University School of Medicine. “Taking a closer look at the basic, scientific basis for sex distinctions in high blood pressure may eventually assist clinicians believe about high blood pressure treatment in brand-new methods.”Pluznick is a fundamental researcher who has found unique roles for so-called olfactory receptors in different organs of the body. The tiny proteins on the surface of cells basically seek nearby odors or other chemicals.Olfr558 RNA (stained magenta) is expressed in kidney vascular smooth muscle cells (left) and renin-positive cells (right). Credit: Jiaojiao Xu and Jennifer Pluznick, Johns Hopkins MedicineThe Johns Hopkins team began their research studies looking for the places in the body where a specific olfactory receptor– Olfr558– is discovered. Olfr558 is one of three olfactory receptors (out of about 350 overall) that are well-conserved by evolution in many mammals, including mice and humans. The human version of the receptor is called OR51E1.Previously, the Johns Hopkins team discovered Olfr558 in the kidney, and other research studies have actually found the receptor in other organs, aside from the cells responsible for scent detection in the nose.For this study, the scientists found the receptor in blood vessel cells in the kidney and in juxtaglomerular granular cells, a kind of kidney cell that produces the hormone renin, which plays a key role in regulating high blood pressure.”This was our very first indicator that we need to take a better take a look at the effect of Olfr558 on high blood pressure,” states Pluznick.Findings and Future DirectionsNext, the group, led by Pluznick and research associate Jiaojiao Xu, Ph.D., determined high blood pressure in young female and male mice throughout active and resting timeframes. Male mice with normal levels of the Olfr558 receptor generally had diastolic and systolic high blood pressure 10 points higher than female mice.However, when the scientists took a look at young female and male mice genetically engineered to do not have the gene for the Olfr558 receptor, they found that high blood pressure increased in female mice however decreased in male mice, such that the sex distinction in blood pressure disappeared.Preliminary data from the Johns Hopkins group indicate capillary tightness and renin hormonal agent levels in the blood as possible factors for the lack of high blood pressure variation in mice without the receptor.The research team likewise evaluated genomic info on human tissue data kept in the U.K. Biobank, concentrating on individuals with an unusual variation in the human variation of the olfactory receptor OR51E1. Their analysis revealed that females and males younger than 50 with the version do disappoint the normal sex-linked distinctions in blood pressure.The research study team warned that their work has actually not identified a direct molecular signaling pathway that would select the link between the olfactory receptor and high blood pressure variation. Those research studies have yet to be done.Pluznicks group will attempt, in future experiments, to determine the accurate cell types that govern the receptor-blood pressure link.”We hope that enhancing our understanding of the fundamental biology of this new link will provide insights on blood pressure policy for both sexes,” states Pluznick.Reference: “An evolutionarily conserved olfactory receptor is needed for sex differences in blood pressure” by Jiaojiao Xu, Rira Choi, Kunal Gupta, Helen R. Warren, Lakshmi Santhanam and Jennifer L. Pluznick, 20 March 2024, Science Advances.DOI: 10.1126/ sciadv.adk1487Support for this research study was provided by the National Institutes of Healths National Institute of Diabetes and Digestive and Kidney Diseases [R56DK107726], the National Institute on Aging [R21AG081683], the American Heart Association Established Investigator Award, the NIHR Cardiovascular Biomedical Centre at Barts and the Queen Mary University of London.In addition to Pluznick and Xu, researchers who contributed to this study are Rira Choi, Kunal Gupta and Lakshmi Santhanam from Johns Hopkins and Helen Warren from the Queen Mary University of London.
Research study shows a cell surface protein, understood for detecting odors, might be key to understanding why blood pressure differs in between sexes, leading to potential changes in how blood pressure is dealt with for guys and women.Johns Hopkins Medicine researchers discovered that a protein receptor involved in noticing odors might explain sex differences in blood pressure.Using data from both people and mice, a Johns Hopkins Medicine research group has found that a cell surface area protein that senses smells and chemicals may be accountable for– and assist describe– sex differences in mammalian blood pressure. The unusual connection between such protein receptors and sex distinctions in blood pressure, reported in the March 20 problem of Science Advances, may lead to a much better understanding of long-known distinctions in blood pressure between females and males.Scientific Investigation Into Olfactory ReceptorsBlood pressure in premenopausal human and mouse women is generally 10 points lower in both systolic and diastolic pressure than in males. Male mice with normal levels of the Olfr558 receptor normally had systolic and diastolic blood pressure 10 points higher than female mice.However, when the researchers looked at young female and male mice genetically crafted to lack the gene for the Olfr558 receptor, they discovered that blood pressure increased in female mice however decreased in male mice, such that the sex distinction in blood pressure disappeared.Preliminary information from the Johns Hopkins team point to blood vessel stiffness and renin hormone levels in the blood as possible reasons for the lack of blood pressure variation in mice without the receptor.The research study group likewise evaluated genomic details on human tissue information stored in the U.K. Biobank, focusing on individuals with an uncommon variation in the human variation of the olfactory receptor OR51E1.
