By National University of Singapore, Yong Loo Lin School of Medicine March 23, 2024A groundbreaking research study discovered that trigonelline, discovered in coffee and fenugreek, increases muscle health in aging by enhancing NAD+ levels and mitochondrial function, using brand-new strategies for healthy aging and illness prevention.A research study consortium led by Nestlé Research in Switzerland and the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) made a current discovery that the natural particle trigonelline present in coffee, fenugreek, and likewise in the human body, can help to improve muscle health and function.In an international cooperation amongst the University of Southampton, University of Melbourne, University of Tehran, University of South Alabama, University of Toyama, and University of Copenhagen, the work develops on a previous collective research study that explained unique mechanisms of human sarcopenia.Sarcopenia is a condition where cellular changes that take place during aging gradually damage the muscles in the body and lead to faster loss of muscle mass, strength and lowered physical independence.One essential problem throughout sarcopenia is that the cellular cofactor NAD+ declines during aging, while mitochondria, the energy powerhouses in our cells, produce less energy. Offering this molecule in pre-clinical designs resulted in increased levels of NAD+, increased mitochondrial activity, and contributed to the maintenance of muscle function during aging.Nutritional Approaches to Combat AgingNAD+ levels can be enhanced with various dietary precursors like the important amino acid L-tryptophan (L-Trp), and vitamin B3 forms such as nicotinic acid (NA), nicotinamide (NAM), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). The benefits of trigonelline on cellular metabolism and muscle health during aging opens appealing translational applications,” said Jerome Feige, Head of the Physical Health department at Nestlé Research.Reference: “Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia” by Mathieu Membrez, Eugenia Migliavacca, Stefan Christen, Keisuke Yaku, Jennifer Trieu, Alaina K. Lee, Francesco Morandini, Maria Pilar Giner, Jade Stiner, Mikhail V. Makarov, Emma S. Garratt, Maria F. Vasiloglou, Lucie Chanvillard, Emilie Dalbram, Amy M. Ehrlich, José Luis Sanchez-Garcia, Carles Canto, Leonidas G. Karagounis, Jonas T. Treebak, Marie E. Migaud, Ramin Heshmat, Farideh Razi, Neerja Karnani, Afshin Ostovar, Farshad Farzadfar, Stacey K. H. Tay, Matthew J. Sanders, Karen A. Lillycrop, Keith M. Godfrey, Takashi Nakagawa, Sofia Moco, René Koopman, Gordon S. Lynch, Vincenzo Sorrentino and Jerome N. Feige, 19 March 2024, Nature Metabolism.DOI: 10.1038/ s42255-024-00997-x.