The research study Expanding the Horizon of the Xeno Nucleic Acid Space: Threose Nucleic Acids with Increased Information Storage was published in the Journal of the American Chemical Society.Structural contrast of DNA and the artificial TNA, a Xeno nucleic acid with the natural base pairs AT and GC and an extra base pair (XY).” Our threofuranosyl nucleic acid is more stable than the naturally occurring nucleic acids DNA and RNA, which brings many benefits for future healing usage,” said Professor Dr Stephanie Kath-Schorr. TNAs might also be utilized for the targeted transport of drugs to particular organs in the body (targeted drug shipment) as well as in diagnostics; they might also be useful for the acknowledgment of viral proteins or biomarkers.Reference: “Expanding the Horizon of the Xeno Nucleic Acid Space: Threose Nucleic Acids with Increased Information Storage” by Hannah Depmeier and Stephanie Kath-Schorr, 5 March 2024, Journal of the American Chemical Society.DOI: 10.1021/ jacs.3 c14626.
Groundbreaking research study has actually led to the creation of threofuranosyl nucleic acid (TNA), offering boosted stability and healing capacity, with applications in drug delivery and diagnostics. Credit: SciTechDaily.comGroundbreaking research has actually led to the development of threofuranosyl nucleic acid (TNA), offering boosted stability and therapeutic capacity, with applications in drug shipment and diagnostics.The DNA carries the hereditary information of all living organisms and includes only four different foundation, the nucleotides. Nucleotides are made up of three distinct parts: a sugar molecule, a phosphate group, and one of the 4 nucleobases adenine, guanine, cytosine, and thymine. The nucleotides are lined up countless times and form the DNA double helix, comparable to a spiral staircase.Breakthrough in Nucleic Acid ResearchScientists from the Breakthrough in Nucleic Acid Researchs Department of Chemistry have actually now shown that the structure of nucleotides can be modified to a great level in the lab. The scientists developed so-called threofuranosyl nucleic acid (TNA) with a brand-new, extra base pair. These are the first steps on the way to completely artificial nucleic acids with improved chemical performances. The study Expanding the Horizon of the Xeno Nucleic Acid Space: Threose Nucleic Acids with Increased Information Storage was released in the Journal of the American Chemical Society.Structural contrast of DNA and the artificial TNA, a Xeno nucleic acid with the natural base sets AT and GC and an extra base set (XY). Credit: Stephanie Kath-SchorrPotential of Artificial Nucleic AcidsArtificial nucleic acids vary in structure from their originals. These changes impact their stability and function.” Our threofuranosyl nucleic acid is more steady than the naturally occurring nucleic acids DNA and RNA, which brings many advantages for future healing use,” stated Professor Dr Stephanie Kath-Schorr. For the study, the 5-carbon sugar deoxyribose, which forms the backbone in DNA, was replaced by a 4-carbon sugar. In addition, the variety of nucleobases was increased from 4 to 6. By exchanging the sugar, the TNA is not acknowledged by the cells own degradation enzymes. This has been a problem with nucleic acid-based therapeutics, as synthetically produced RNA that is presented into a cell is quickly degraded and loses its impact. The intro of TNAs into cells that stay undiscovered might now keep the result for longer.” In addition, the built-in abnormal base pair enables alternative binding alternatives to target particles in the cell,” added Hannah Depmeier, lead author of the study.Kath-Schorr is certain that such a function can be used in specific in the development of brand-new aptamers, short DNA or RNA sequences, which can be utilized for the targeted control of cellular systems. TNAs might also be utilized for the targeted transport of drugs to specific organs in the body (targeted drug delivery) along with in diagnostics; they could likewise work for the acknowledgment of viral proteins or biomarkers.Reference: “Expanding the Horizon of the Xeno Nucleic Acid Space: Threose Nucleic Acids with Increased Information Storage” by Hannah Depmeier and Stephanie Kath-Schorr, 5 March 2024, Journal of the American Chemical Society.DOI: 10.1021/ jacs.3 c14626.
