A recent study by the URV has revealed that a diet plan high in hydrogenated fats accelerates Alzheimers development by affecting blood and brain molecules, opening brand-new avenues for treatment and prevention.This research, performed by Universitat Rovira i Virgili, advances our understanding of how obesity, type 2 diabetes, and Alzheimers illness are interconnected.A study performed by the URV has revealed the process by which a diet plan high in hydrogenated fats adds to Alzheimers disease. This research study centered on the impact of such a diet on specific particles present in the blood and other tissues like the brain, which function as indications and controllers of the disease.The research study was headed by Mònica Bulló, professor at the Department of Biochemistry and Biotechnology and member of the Metabolic Health and Nutrition unit and the Environmental, Food and Toxicological Technology Centre (TecnATox) of the URV, in collaboration with the Pere Virgili Health Research Institute (IISPV), CIBERobn and the University of Barcelona. The outcomes have been released in the journal Nutrients.The research was conducted on mice models who established Alzheimers illness in their adult years. Previous studies in these animals had actually already shown that after a diet high in hydrogenated fats the mice developed Alzheimers much earlier than mice on a standard diet. The systems that led to the beginning of Alzheimers remained unknown. That is, till now.Key Findings on Molecular ChangesThe scientists evaluated the expression of 15 miRNAs, little molecules of RNA that play a vital function in genetic guideline in both plasma and brain tissues. The group analyzed modifications in insulin-related miRNAs in mouse designs predisposed to Alzheimers not on a diet low in saturated fats.An image of the research study group. Credit: Universitat Rovira i VirgiliThe results showed that their metabolic process intensified after being on this diet for 6 months: their body weight increased substantially and their action to glucose and insulin decreased. These exact same attributes can also be discovered in people with weight problems or type 2 diabetes. Additionally, researchers discovered modifications to numerous miRNAs in both the brain and the blood. These changes were associated with processes that can trigger mental retardation, such as the build-up of β-amyloid plaques (protein deposits that form in the brain and which are markers of Alzheimers), excessive production of the tau protein (which can damage brain cells when it leaves control) and swelling in the brain.” The outcomes of this study are a step forward in our understanding of this illness and may describe the relationship between weight problems, type 2 diabetes, and the beginning of Alzheimers. The findings also use new targets for the possible avoidance and treatment of the illness”, said researcher Mònica BullóThe study not only offers new information on how a high-fat diet plan can impact the health of the brain, however also opens the door to future research into dietary strategies as a method of dealing with Alzheimers. The outcomes highlight the value of a well balanced diet plan in avoiding neurodegenerative illness and emphasize miRNAs as targets for therapeutic interventions.Reference: “Effects of a High-Fat Diet on Insulin-Related miRNAs in Plasma and Brain Tissue in APPSwe/PS1dE9 and Wild-Type C57BL/6J Mice” by Melina Rojas-Criollo, Nil Novau-Ferré, Laia Gutierrez-Tordera, Miren Ettcheto, Jaume Folch, Christopher Papandreou, Laura Panisello, Amanda Cano, Hamza Mostafa, Javier Mateu-Fabregat, Marina Carrasco, Antoni Camins and Mònica Bulló, 25 March 2024, Nutrients.DOI: 10.3390/ nu16070955.