The research study suggests that both brain and muscle clocks must operate harmoniously to prevent muscle aging, with consuming patterns also playing an important function in managing these clocks.A current research study in mice has actually exposed that molecular circadian clocks in the brain and muscle tissue work together to maintain muscle health and daily function. Previous research has revealed that mice doing not have the circadian clock gene Bmal1 show interfered with muscle clock rhythmicity as well as premature aging and muscle wasting.Using a novel international Bmal1 knockout mouse model that avoids Bmal1 expression but enables Bmal1 function to be reconstituted in any tissue of option, Arun Kumar and coworkers investigated the interactions in between the brain and muscle clocks and whether the disruption of these interactions contributes to the overserved impacts of muscle aging in mice. Kumar et al. restored clock function in three mouse lines via targeted expression of Bmal1 in the brain or skeletal muscle tissue or both and found that restoration of both clocks was needed to prevent premature aging and muscle dysfunction, recommending that this brain-muscle interaction is required for appropriate muscle function and health.The authors also show that time-restricted feeding during the active dark phase (nighttime) might partially replace the function of the main clock in the brain and improve the overall autonomy of the muscle clock, underscoring the value of eating patterns on molecular clock interactions.
