Our work integrates the precision of aging clocks with the build-up of completely stochastic changes in our cells,” stated Professor Schumacher.Less checks, more noiseWith increasing age, managing the processes that occur in our cells becomes less efficient, resulting in more stochastic outcomes. The high variation indicative of the age of the body cells was undoubtedly reversed to the low stochastic sound of young stem cells.Meyer and Schumacher hope that their findings on the loss of guideline and the collecting stochastic variations will lead to brand-new interventions that can take on the root cause of aging and might even lead to cellular rejuvenation. A target for such interventions might be fixing stochastic modifications in DNA or enhanced control of gene expression.Reference: “Aging clocks based on accumulating stochastic variation” by David H. Meyer, and Björn Schumacher, 9 May 2024, Nature Aging.DOI: 10.1038/ s43587-024-00619-x.
Our work combines the accuracy of aging clocks with the accumulation of completely stochastic modifications in our cells,” stated Professor Schumacher.Less checks, more noiseWith increasing age, controlling the procedures that occur in our cells becomes less reliable, resulting in more stochastic outcomes. The high variation indicative of the age of the body cells was indeed reversed to the low stochastic sound of young stem cells.Meyer and Schumacher hope that their findings on the loss of regulation and the accumulating stochastic variations will lead to new interventions that can tackle the root cause of aging and might even lead to cellular rejuvenation. A target for such interventions could be repairing stochastic modifications in DNA or enhanced control of gene expression.Reference: “Aging clocks based on collecting stochastic variation” by David H. Meyer, and Björn Schumacher, 9 May 2024, Nature Aging.DOI: 10.1038/ s43587-024-00619-x.