The 2021 Global Burden of Disease Study forecasts a rise in global life expectancy by 2024-2050, driven by effective public health strategies and a shift in disease burden from communicable to non-communicable diseases, with a focus on reducing disparities and addressing metabolic and lifestyle-related risks.
The most recent results from the Global Burden of Disease Study (GBD) 2021, recently published in The Lancet, predict a rise in global life expectancy of 4.9 years for males and 4.2 years for females from 2022 to 2050.
Increases are expected to be largest in countries where life expectancy is lower, contributing to a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and a range of communicable, maternal, neonatal, and nutritional diseases (CMNNs).
This study indicates that the ongoing shift in disease burden to non-communicable diseases (NCDs) – like cardiovascular diseases, cancer, chronic obstructive pulmonary disease, and diabetes – and exposure to NCD-associated risk factors – such as obesity, high blood pressure, non-optimal diet, and smoking – will have the greatest impact on disease burden of the next generation.
As the disease burden continues to shift from CMNNs to NCDs and from years of life lost (YLLs) to years lived with disability (YLDs), more people are expected to live longer, but with more years spent in poor health. Global life expectancy is forecasted to increase from 73.6 years of age in 2022 to 78.1 years of age in 2050 (a 4.5-year increase). Global healthy life expectancy (HALE) – the average number of years a person can expect to live in good health – will increase from 64.8 years in 2022 to 67.4 years in 2050 (a 2.6-year increase).
Study Methodology and Results
To come to these conclusions, the study forecasts cause-specific mortality; YLLs; YLDs; disability-adjusted life years (DALYs, or lost years of healthy life due to poor health and early death); life expectancy; and HALE from 2022 through 2050 for 204 countries and territories.
“In addition to an increase in life expectancy overall, we have found that the disparity in life expectancy across geographies will lessen,” said Dr. Chris Murray, Chair of Health Metrics Sciences at the University of Washington and Director of the Institute for Health Metrics and Evaluation (IHME). “This is an indicator that while health inequalities between the highest- and lowest-income regions will remain, the gaps are shrinking, with the biggest increases anticipated in sub-Saharan Africa.”
Dr. Murray added that the biggest opportunity to speed up reductions in the global disease burden is through policy interventions aimed to prevent and mitigate behavioral and metabolic risk factors.
These findings build upon the results of the GBD 2021 risk factors study, also released in The Lancet. This accompanying study found that the total number of years lost due to poor health and early death (measured in DALYs) attributable to metabolic risk factors has increased by 50% since 2000.
The study also puts forth various alternative scenarios to compare the potential health outcomes if different public health interventions could eliminate exposure to several key risk factor groups by 2050.
“We forecast large differences in global DALY burden between different alternative scenarios to see what is the most impactful on our overall life expectancy data and DALY forecasts,” said Dr. Stein Emil Vollset, first author of the study who leads the GBD Collaborating Unit at the Norwegian Institute of Public Health. “Globally, the forecasted effects are strongest for the ‘Improved Behavioral and Metabolic Risks’ scenario, with a 13.3% reduction in disease burden (number of DALYs) in 2050 compared with the ‘Reference’ (most likely) scenario.”
The authors also ran two more scenarios: one focused on safer environments and another on improved childhood nutrition and vaccination.
“Though the largest effects in global DALY burden were seen from the ‘Improved Behavioral and Metabolic Risk’ scenario, we also forecasted reductions in disease burden from the ‘Safer Environment’ and ‘Improved Childhood Nutrition and Vaccination’ scenarios beyond our reference forecast, said Amanda E. Smith, Assistant Director of Forecasting at IHME. “This demonstrates the need for continued progress and resources in these areas and the potential to accelerate progress through 2050.”
“There is immense opportunity ahead for us to influence the future of global health by getting ahead of these rising metabolic and dietary risk factors, particularly those related to behavioral and lifestyle factors like high blood sugar, high body mass index, and high blood pressure,” continued Dr. Murray.
Reference: “Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021” by Stein Emil Vollset, Hazim S Ababneh, Yohannes Habtegiorgis Abate, Cristiana Abbafati, Rouzbeh Abbasgholizadeh, Mohammadreza Abbasian, Hedayat Abbastabar, Abdallah H A Abd Al Magied, Samar Abd ElHafeez, Atef Abdelkader, Michael Abdelmasseh, Sherief Abd-Elsalam, Parsa Abdi, Mohammad Abdollahi, Meriem Abdoun, Auwal Abdullahi, Mesfin Abebe, Olumide Abiodun, Richard Gyan Aboagye, Hassan Abolhassani, Mohamed Abouzid, Girma Beressa Aboye, Lucas Guimarães Abreu, Abdorrahim Absalan, Hasan Abualruz, Bilyaminu Abubakar, Hana Jihad Jihad Abukhadijah, Giovanni Addolorato, Victor Adekanmbi, Charles Oluwaseun Adetunji, Juliana Bunmi Adetunji, Temitayo Esther Adeyeoluwa, Rishan Adha, Ripon Kumar Adhikary, Qorinah Estiningtyas Sakilah Adnani, Leticia Akua Adzigbli, Fatemeh Afrashteh, Muhammad Sohail Afzal, Saira Afzal, Faith Agbozo, Antonella Agodi, Anurag Agrawal, Williams Agyemang-Duah, Bright Opoku Ahinkorah, Austin J Ahlstrom, Aqeel Ahmad, Firdos Ahmad, Muayyad M Ahmad, Sajjad Ahmad, Shahzaib Ahmad, Anisuddin Ahmed, Ayman Ahmed, Haroon Ahmed, Safoora Ahmed, Syed Anees Ahmed, Karolina Akinosoglou, Mohammed Ahmed Akkaif, Ashley E Akrami, Ema Akter, Salah Al Awaidy, Syed Mahfuz Al Hasan, Amjad S Al Mosa, Omar Al Ta’ani, Omar Ali Mohammed Al Zaabi, Fares Alahdab, Muaaz M Alajlani, Yazan Al-Ajlouni, Samer O Alalalmeh, Ziyad Al-Aly, Khurshid Alam, Noore Alam, Tahiya Alam, Zufishan Alam, Rasmieh Mustafa Al-amer, Fahad Mashhour Alanezi, Turki M Alanzi, Almaza Albakri, Wafa A Aldhaleei, Robert W Aldridge, Seyedeh Yasaman Alemohammad, Yihun Mulugeta Alemu, Adel Ali Saeed Al-Gheethi, Mohammed Khaled Al-Hanawi, Abid Ali, Amjad Ali, Iman Ali, Mohammed Usman Ali, Rafat Ali, Syed Shujait Shujait Ali, Victor Ekoche Ali, Waad Ali, Akram Al-Ibraheem, Gianfranco Alicandro, Sheikh Mohammad Alif, Syed Mohamed Aljunid, François Alla, Joseph Uy Almazan, Hesham M Al-Mekhlafi, Ahmed Yaseen Alqutaibi, Ahmad Alrawashdeh, Sahel Majed Alrousan, Salman Khalifah Al-Sabah, Mohammed A Alsabri, Zaid Altaany, Ala’a B. Al-Tammemi, Jaffar A Al-Tawfiq, Khalid A Altirkawi, Deborah Oyine Aluh, Nelson Alvis-Guzman, Mohammad Sami Al-Wardat, Yaser Mohammed Al-Worafi, Hany Aly, Mohammad Sharif Alyahya, Karem H Alzoubi, Walid Al-Zyoud, Reza Amani, Edward Kwabena Ameyaw, Tarek Tawfik Amin, Alireza Amindarolzarbi, Sohrab Amiri, Mohammad Hosein Amirzade-Iranaq, Hubert Amu, Dickson A Amugsi, Robert Ancuceanu, Deanna Anderlini, David B Anderson, Pedro Prata Andrade, Catalina Liliana Andrei, Tudorel Andrei, Erick Adrian Andrews, Abhishek Anil, Sneha Anil, Amir Anoushiravani, Catherine M Antony, Ernoiz Antriyandarti, Boluwatife Stephen Anuoluwa, Saeid Anvari, Anayochukwu Edward Anyasodor, Francis Appiah, Michele Aquilano, Juan Pablo Arab, Jalal Arabloo, Elshaimaa A Arafa, Mosab Arafat, Aleksandr Y Aravkin, Ali Ardekani, Demelash Areda, Brhane Berhe Aregawi, Abdulfatai Aremu, Hany Ariffin, Mesay Arkew, Keivan Armani, Anton A Artamonov, Ashokan Arumugam, Mohammad Asghari-Jafarabadi, Charlie Ashbaugh, Thomas Astell-Burt, Seyyed Shamsadin Athari, Prince Atorkey, Maha Moh’d Wahbi Atout, Avinash Aujayeb, Marcel Ausloos, Hamzeh Awad, Adedapo Wasiu Awotidebe, Haleh Ayatollahi, Jose L Ayuso-Mateos, Sina Azadnajafabad, Fahad Khan Azeez, Rui M S Azevedo, Muhammad Badar, Soroush Baghdadi, Mahboube Bagheri, Nasser Bagheri, Ruhai Bai, Jennifer L Baker, Abdulaziz T Bako, Senthilkumar Balakrishnan, Wondu Feyisa Balcha, Ovidiu Constantin Baltatu, Martina Barchitta, Erfan Bardideh, Suzanne Lyn Barker-Collo, Till Winfried Bärnighausen, Hiba Jawdat Barqawi, Sandra Barteit, Afisu Basiru, João Diogo Basso, Mohammad-Mahdi Bastan, Sanjay Basu, Matteo Bauckneht, Bernhard T Baune, Mohsen Bayati, Nebiyou Simegnew Bayileyegn, Amir Hossein Behnoush, Payam Behzadi, Maryam Beiranvand, Olorunjuwon Omolaja Bello, Luis Belo, Apostolos Beloukas, Maryam Bemanalizadeh, Isabela M Bensenor, Habib Benzian, Azizullah Beran, Zombor Berezvai, Robert S Bernstein, Paulo J G Bettencourt, Kebede A Beyene, Melak Gedamu Beyene, Devidas S Bhagat, Akshaya Srikanth Bhagavathula, Neeraj Bhala, Dinesh Bhandari, Ravi Bharadwaj, Nikha Bhardwaj, Pankaj Bhardwaj, Ashish Bhargava, Sonu Bhaskar, Vivek Bhat, Natalia V Bhattacharjee, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti, Manpreet S Bhatti, Mohiuddin Ahmed Bhuiyan, Catherine Bisignano, Bijit Biswas, Tone Bjørge, Virginia Bodolica, Aadam Olalekan Bodunrin, Milad Bonakdar Hashemi, Berrak Bora Basara, Hamed Borhany, Samuel Adolf Bosoka, Alejandro Botero Carvajal, Souad Bouaoud, Soufiane Boufous, Christopher Boxe, Edward J Boyko, Oliver J Brady, Dejana Braithwaite, Michael Brauer, Javier Brazo-Sayavera, Hermann Brenner, Colin Stewart Brown, Annie J Browne, Traolach Brugha, Dana Bryazka, Norma B Bulamu, Danilo Buonsenso, Katrin Burkart, Richard A Burns, Reinhard Busse, Yasser Bustanji, Zahid A Butt, Florentino Luciano Caetano dos Santos, Mehtap Çakmak Barsbay, Daniela Calina, Luciana Aparecida Campos, Shujin Cao, Angelo Capodici, Rosario Cárdenas, Giulia Carreras, Andrea Carugno, Márcia Carvalho, Joao Mauricio Castaldelli-Maia, Giulio Castelpietra, Maria Sofia Cattaruzza, Arthur Caye, Luca Cegolon, Francieli Cembranel, Edina Cenko, Ester Cerin, Steven J Chadban, Joshua Chadwick, Chiranjib Chakraborty, Sandip Chakraborty, Julian Chalek, Jeffrey Shi Kai Chan, Rama Mohan Chandika, Sara Chandy, Jaykaran Charan, Anis Ahmad Chaudhary, Akhilanand Chaurasia, An-Tian Chen, Haowei Chen, Meng Xuan Chen, Simiao Chen, Nicolas Cherbuin, Gerald Chi, Fatemeh Chichagi, Odgerel Chimed-Ochir, Ritesh Chimoriya, Patrick R Ching, Jesus Lorenzo Chirinos-Caceres, Abdulaal Chitheer, Daniel Youngwhan Cho, William C S Cho, Dong-Woo Choi, Bryan Chong, Chean Lin Chong, Hitesh Chopra, Dinh-Toi Chu, Eric Chung, Muhammad Chutiyami, Justin T Clayton, Rebecca M Cogen, Aaron J Cohen, Alyssa Columbus, Haley Comfort, Joao Conde, Jon T Connolly, Ezra E K Cooper, Samuele Cortese, Natália Cruz-Martins, Alanna Gomes da Silva, Omid Dadras, Xiaochen Dai, Zhaoli Dai, Bronte E Dalton, Giovanni Damiani, Lalit Dandona, Rakhi Dandona, Jai K Das, Saswati Das, Subasish Das, Nihar Ranjan Dash, Kairat Davletov, Fernando Pio De la Hoz, Diego De Leo, Shayom Debopadhaya, Ivan Delgado-Enciso, Edgar Denova-Gutiérrez, Nikolaos Dervenis, Hardik Dineshbhai Desai, Vinoth Gnana Chellaiyan Devanbu, Syed Masudur Rahman Dewan, Kuldeep Dhama, Amol S Dhane, Sameer Dhingra, Diana Dias da Silva, Daniel Diaz, Luis Antonio Diaz, Michael J Diaz, Adriana Dima, Delaney D Ding, Thao Huynh Phuong Do, Camila Bruneli do Prado, Masoud Dodangeh, Milad Dodangeh, Phidelia Theresa Doegah, Sushil Dohare, Wanyue Dong, Mario D’Oria, Rajkumar Doshi, Robert Kokou Dowou, Haneil Larson Dsouza, Viola Dsouza, John Dube, Samuel C Dumith, Bruce B Duncan, Andre Rodrigues Duraes, Senbagam Duraisamy, Oyewole Christopher Durojaiye, Anar Dushpanova, Sulagna Dutta, Paulina Agnieszka Dzianach, Arkadiusz Marian Dziedzic, Ejemai Eboreime, Alireza Ebrahimi, Mohammad Ebrahimi Kalan, Hisham Atan Edinur, Ferry Efendi, Terje Andreas Eikemo, Ebrahim Eini, Temitope Cyrus Ekundayo, Rabie Adel El Arab, Iman El Sayed, Osman Elamin, Noha Mousaad Elemam, Ghada Metwally Tawfik ElGohary, Muhammed Elhadi, Omar Abdelsadek Abdou Elmeligy, Adel B Elmoselhi, Mohammed Elshaer, Ibrahim Elsohaby, Mohd. Elmagzoub Eltahir, Theophilus I Emeto, Babak Eshrati, Majid Eslami, Zahra Esmaeili, Natalia Fabin, Adeniyi Francis Fagbamigbe, Omotayo Francis Fagbule, Luca Falzone, Mohammad Fareed, Carla Sofia e Sá Farinha, MoezAlIslam Ezzat Mahmoud Faris, Andre Faro, Kiana Fasihi, Ali Fatehizadeh, Nelsensius Klau Fauk, Timur Fazylov, Valery L Feigin, Ginenus Fekadu, Xiaoqi Feng, Seyed-Mohammad Fereshtehnejad, Pietro Ferrara, Nuno Ferreira, Belete Sewasew Firew, Florian Fischer, Ida Fitriana, Joanne Flavel, Luisa S Flor, Morenike Oluwatoyin Folayan, Kristen Marie Foley, Marco Fonzo, Lisa M Force, Matteo Foschi, Alberto Freitas, Ni Kadek Yuni Fridayani, Kai Glenn Fukutaki, João M Furtado, Blima Fux, Peter Andras Gaal, Muktar A Gadanya, Silvano Gallus, Balasankar Ganesan, Mohammad Arfat Ganiyani, Rupesh K Gautam, Tilaye Gebru Gebi, Miglas W Gebregergis, Mesfin Gebrehiwot, Lemma Getacher, Genanew K A Getahun, Peter W Gething, Delaram J Ghadimi, Fataneh Ghadirian, Sadegh Ghafarian, Khalid Yaser Ghailan, MohammadReza Ghasemi, Ghazal Ghasempour Dabaghi, Ramy Mohamed Ghazy, Sama Ghoba, Ehsan Gholami, Ali Gholamrezanezhad, Nasim Gholizadeh, Mahsa Ghorbani, Pooyan Ghorbani Vajargah, Elena Ghotbi, Artyom Urievich Gil, Tiffany K Gill, Alem Girmay, James C Glasbey, Ekaterina Vladimirovna Glushkova, Elena V Gnedovskaya, Laszlo Göbölös, Mohamad Goldust, Pouya Goleij, Davide Golinelli, Sameer Vali Gopalani, Alessandra C Goulart, Mahdi Gouravani, Anmol Goyal, Michal Grivna, Giuseppe Grosso, Giovanni Guarducci, Mohammed Ibrahim Mohialdeen Gubari, Stefano Guicciardi, Rafael Alves Guimarães, Snigdha Gulati, David Gulisashvili, Damitha Asanga Gunawardane, Cui Guo, Anish Kumar Gupta, Rahul Gupta, Rajeev Gupta, Renu Gupta, Sapna Gupta, Vijai Kumar Gupta, Annie Haakenstad, Najah R Hadi, Nils Haep, Abdul Hafiz, Dariush Haghmorad, Demewoz Haile, Adel Hajj Ali, Ali Hajj Ali, Arvin Haj-Mirzaian, Esam S Halboub, Sebastian Haller, Rabih Halwani, Kanaan Hamagharib Abdullah, Nadia M Hamdy, Rifat Hamoudi, Nasrin Hanifi, Graeme J Hankey, Zaim Anan Haq, Md Rabiul Haque, Harapan Harapan, Arief Hargono, Josep Maria Haro, Ahmed I Hasaballah, S. M. Mahmudul Hasan, Mohammad Hasanian, Md Saquib Hasnain, Amr Hassan, Johannes Haubold, Simon I Hay, Jeffrey J Hebert, Omar E Hegazi, Mohammad Heidari, Mehdi Hemmati, Claire A Henson, Brenda Yuliana Herrera-Serna, Claudiu Herteliu, Majid Heydari, Kamal Hezam, Irma Hidayana, Yuta Hiraike, Nguyen Quoc Hoan, Ramesh Holla, Praveen Hoogar, Nobuyuki Horita, Md Mahbub Hossain, Hassan Hosseinzadeh, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Chengxi Hu, Junjie Huang, Michael Hultström, Tsegaye Gebreyes Hundie, Aliza J Hunt, Kiavash Hushmandi, Javid Hussain, M. Azhar Hussain, Nawfal R Hussein, Hong-Han Huynh, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Pulwasha Maria Iftikhar, Adalia I Ikiroma, Paul Chukwudi Ikwegbue, Irena M Ilic, Milena D Ilic, Mustapha Immurana, Mustafa Alhaji Isa, Md. Rabiul Islam, Sheikh Mohammed Shariful Islam, Faisal Ismail, Nahlah Elkudssiah Ismail, Gaetano Isola, Masao Iwagami, Ihoghosa Osamuyi Iyamu, Louis Jacob, Kathryn H Jacobsen, Morteza Jafarinia, Kasra Jahankhani, Nader Jahanmehr, Nityanand Jain, Ammar Abdulrahman Jairoun, Dr Ruchi Jakhmola Mani, Safayet Jamil, Roland Dominic G Jamora, Abubakar Ibrahim Jatau, Sabzali Javadov, Tahereh Javaheri, Shubha Jayaram, Sun Ha Jee, Jayakumar Jeganathan, Heng Jiang, Mohammad Jokar, Jost B Jonas, Nitin Joseph, Charity Ehimwenma Joshua, Mikk Jürisson, Vaishali K, Ali Kabir, Zubair Kabir, Vidya Kadashetti, Laleh R Kalankesh, Sanjay Kalra, … Uzma Zafar, Nima Zafari, Mondal Hasan Zahid, Fathiah Zakham, Nazar Zaki, Taddese Alemu Zerfu, Haijun Zhang, Jingya Zhang, Liqun Zhang, Yunquan Zhang, Zhiqiang Zhang, Xiu-Ju George Zhao, Yang Zhao, Zhongyi Zhao, Chenwen Zhong, Bolun Zhou, Juexiao Zhou, Shangcheng Zhou, Bin Zhu, Abzal Zhumagaliuly, Magdalena Zielińska, Ghazal Zoghi, Alimuddin Zumla, Sa’ed H Zyoud, Samer H Zyoud, Amanda E Smith and Christopher J L Murray, 18 May 2024, The Lancet.
DOI: 10.1016/S0140-6736(24)00685-8
