A University of Georgia study reveals that fish oil supplements may help individuals genetically predisposed to high cholesterol by lowering levels of LDL, total cholesterol, and triglycerides, offering a potential strategy for managing cardiovascular risk. Credit: SciTechDaily.com
Research shows that omega-3 supplements can lower the genetic likelihood of elevated cholesterol, LDL, and triglycerides.
Fish oil supplements represent a multi-billion dollar industry both in the U.S. and internationally, with roughly two out of every 25 individuals consuming these popular omega-3 capsules.
And a new study from the University of Georgia might encourage a new population to start looking into the supplements as well: people with a genetic predisposition to high cholesterol.
Using genetic data from more than 441,000 participants, the researchers calculated a score to predict the genetic likelihood of high levels of total cholesterol, high LDL cholesterol (which is often referred to as “bad” cholesterol), triglycerides and HDL cholesterol (or “good” cholesterol).
“Recent advances in genetic studies have allowed us to predict someone’s genetic risk of high cholesterol,” said Yitang Sun, a recent doctoral graduate from UGA’s Department of Genetics. “But the current prediction has room for improvement because it does not consider individual differences in lifestyles, such as taking fish oil supplements.”
The researchers found that participants who reported taking fish oil supplements had lower blood lipid levels than predicted, especially for total cholesterol, LDL cholesterol, and triglycerides.
Implications of the Study
“Our study shows that considering lifestyles will improve genetic prediction,” said Kaixiong Ye, corresponding author of the study and an assistant professor of genetics in UGA’s Franklin College of Arts and Sciences. “Our findings also support that fish oil supplements may counteract the genetic predisposition to high cholesterol.”
Fish oil counters the effect of family history of high cholesterol It’s no secret that high cholesterol is bad for the body. Arteries start to harden, and the risk of heart attack or stroke increases. While a healthy diet and exercise can help prevent it, the Centers for Disease Control and Prevention estimates that more than 86 million American adults — or about one in four — have high cholesterol.
Millions more are at risk of developing high cholesterol due to a variety of factors including one they can’t control: genetics. For people whose families have a history of high cholesterol, the study’s findings offer another possibility to help safeguard their health.
“Taking fish oil is associated with a shift toward a healthy lipid profile,” Ye said.
The researchers also analyzed the effects of fish oil on HDL cholesterol and found the supplements are beneficial in raising the so-called “good” cholesterol.
Reference: “Fish oil supplementation modifies the associations between genetically predicted and observed concentrations of blood lipids: a cross-sectional gene-diet interaction study in UK Biobank” by Yitang Sun, Tryggvi McDonald, Abigail Baur, Huifang Xu, Naveen Brahman Bateman, Ye Shen, Changwei Li and Kaixiong Ye, 15 July 2024, The American Journal of Clinical Nutrition.
DOI: 10.1016/j.ajcnut.2024.07.009