Previous research study has recommended that utilizing statins to lower LDL-C positively impacts health results, and this is shown in the different iterations of specialist standards for the prevention of CVD. Statins are now frequently prescribed by doctors, with one third of Irish grownups over the age of 50 taking statins, according to previous research study.
The brand-new findings oppose this theory, finding that this relationship was not as strong as previously believed. Instead, the research study demonstrates that decreasing LDL-C using statins had a inconsistent and inconclusive influence on CVD outcomes such as myocardial infarction (MI), stroke, and all-cause mortality.
In addition, it suggests that the total benefit of taking statins might be small and will differ depending upon a persons personal risk aspects.
The lead author on the paper is Dr. Paula Byrne from the HRB Centre for Primary Care Research based in RCSIs Department of General Practice. Discussing the findings, Dr. Byrne said: “The message has long been that reducing your cholesterol will decrease your threat of heart illness, which statins help to achieve this. However, our research study indicates that, in truth, the advantages of taking statins are diverse and can be quite modest.”
The scientists go on to suggest that this updated details must be communicated to clients through notified scientific decision-making and updated clinical guidelines and policy.
Reference: “Evaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment” 14 March 2022, JAMA Internal Medicine.DOI: 10.1001/ jamainternmed.2022.0134.
This important discovery was a collaboration with Professor Susan M Smith, likewise of RCSI and with scientists from the University of New Mexico, USA, (Dr. Robert DuBroff), the Institute for Scientific Freedom in Denmark (Dr Maryanne Demasi), Bond University in Australia (Dr. Mark Jones) and independent researcher Dr. Kirsty OBrien.
RCSI University of Medicine and Health Sciences is a world-leading university for Good Health and Well-being. Ranked 2nd in the world for its contribution to UN Sustainable Development Goal 3 in the Times Higher Education Impact Rankings 2021, it is exclusively focused on education and research study to drive improvements in human health worldwide.
RCSI is a global not-for-profit university, headquartered in Dublin. It is amongst the leading 250 universities worldwide in the World University Rankings (2022 ). RCSI has been granted Athena Swan Bronze accreditation for positive gender practice in higher education.
The lead author on the paper is Dr. Paula Byrne from the HRB Centre for Primary Care Research based in RCSIs Department of General Practice. Our research indicates that, in reality, the benefits of taking statins are varied and can be quite modest.”
It is amongst the leading 250 universities worldwide in the World University Rankings (2022 ).
New research from RCSI University of Medicine and Health Sciences has exposed that the link between bad cholesterol (LDL-C) and bad health results, such as heart attack and stroke, might not be as strong as formerly believed.
Released in JAMA Internal Medicine, the research questions the efficacy of statins when prescribed with the aim of lowering LDL-C and for that reason minimizing the threat of heart disease (CVD).