” Our focus was on the risk molecule S100A9. S100A9, together with numerous saturated fatty acids, causes irregular activation and differentiation of macrophages and ultimately leads to the fact that inflammatory reactions do not subside or skin injuries are not effectively repaired,” explains research study leader Dr. Anja Saalbach, researcher and working group leader at the Department of Dermatology, Venerology and Allergology at Leipzig University Hospital.
Dr. Anja Saalbach, scientist and working group head at Leipzig University Hospitals Department of Dermatology, Venerology, and Allergology, led the research. Credit: Leipzig University
In mouse models, the Leipzig-based scientists have revealed that blocking the threat molecule S100A9 stabilizes the misdirected activation of macrophages in obesity and thus the inflammatory action and injury healing. Another option involved feeding the animals a diet plan with reduced levels of saturated fatty acids. After just one week of dieting, the inflammatory reaction had gone back to typical– without the animals always having actually lost weight.
” Based on our information, it appears that changing a clients diet plan would be enough, even if they do not slim down as a result,” says Dr. Saalbach.
” In a previous research study at Leipzig University Hospital, we showed that saturated fatty acids play a very important role. In mouse designs, simply four weeks of a diet abundant in saturated fatty acids, such as palmitic acid and stearic acid, sufficed to increase the incident of inflammatory skin responses,” discusses study leader Dr. Saalbach, adding: “The information from our research in animal models has actually caused a clinical study now being carried out at the Department of Dermatology to examine whether a change in diet plan would also assist the treatment of psoriasis in humans.” In addition, the threat molecule S100A9 is now an intriguing target structure for researchers in order to normalize misdirected inflammatory responses and wound healing disorders in obesity.
Referral: “Overexpression of S100A9 in obesity hinders macrophage differentiation by means of TLR4-NFkB-signaling intensifying swelling and wound recovery” by Sandra Franz, Anastasia Ertel, Kathrin M Engel, Jan C. Simon and Anja Saalbach, January 2022, Theranostics.DOI: 10.7150/ thno.67174.
Scientists at Leipzig University Hospital were curious to learn why overweight individuals are more likely to establish persistent inflammatory disorders and chronic injuries that do not heal.
S100A9, together with lots of saturated fatty acids, triggers abnormal activation and differentiation of macrophages and ultimately leads to the reality that inflammatory reactions do not subside or skin injuries are not properly fixed,” discusses study leader Dr. Anja Saalbach, scientist and working group leader at the Department of Dermatology, Venerology and Allergology at Leipzig University Hospital. In mouse models, the Leipzig-based scientists have shown that blocking the risk molecule S100A9 stabilizes the misdirected activation of macrophages in obesity and therefore the inflammatory reaction and injury recovery.
University of Leipzig researchers observed that after just one week of dieting, the inflammatory response in mouse models was restored to normal– without the animals always dropping weight.
Researchers from Leipzig University identify new systems for persistent swelling and injury recovery concerns
In regular scientific practice, it has actually been kept in mind that obese individuals are more likely to establish persistent inflammatory conditions like psoriasis at an earlier age and with higher severity. Furthermore, these problems are more tough to treat in people who are obese. Therefore, scientists at Leipzig University Hospital wondered to discover why overweight individuals are most likely to develop chronic inflammatory conditions and chronic injuries that do not heal.
Researchers took a look at how saturated fatty acids impact injury healing and swelling incidence in a research study that was just recently published in the journal Theranostics.