The clinical community has over the last 40 years exposed approximately 100 genes contributing to hereditary heart illness, 80 percent of cases still have unidentified genetic causes. Coming from an engineering, bioinformatics, and developmental genomics background helped Ramialison acknowledge how much about the heart remains to be discovered. Heart disease research study has actually historically centered on bring back function by improving mechanical kinetics and promoting structural repair work, and this has, till just recently, overshadowed the fact that the heart is a dynamic organ. It is becoming clearer with each new research study that the heart is driven by a varied collection of cells– not just contractile cardiomyocytes– continuously reacting to myriad moving physical, electrical, chemical, and genetic signals. Mohenska et al., “3D-cardiomics: A spatial transcriptional atlas of the mammalian heart,” J Mol Cell Cardiol, 163:20 -32, 2022.
The clinical neighborhood has over the last 40 years uncovered approximately 100 genes contributing to hereditary heart disease, 80 percent of cases still have unknown genetic causes. Coming from an engineering, bioinformatics, and developmental genomics background helped Ramialison acknowledge how much about the heart remains to be discovered. Heart disease research has actually historically centered on restoring function by improving mechanical kinetics and promoting structural repair work, and this has, up until just recently, eclipsed the fact that the heart is a dynamic organ.